Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1758833..1759449 Replicon chromosome
Accession NZ_CP015852
Organism Pseudomonas koreensis strain CRS05-R5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A8L59_RS07850 Protein ID WP_064586612.1
Coordinates 1758833..1759045 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A8L59_RS07855 Protein ID WP_064586613.1
Coordinates 1759045..1759449 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L59_RS07825 1754988..1755524 + 537 WP_064586607.1 DsbE family thiol:disulfide interchange protein -
A8L59_RS07830 1755521..1755991 + 471 WP_064586608.1 cytochrome c-type biogenesis protein CcmH -
A8L59_RS07835 1755988..1757190 + 1203 WP_064586609.1 c-type cytochrome biogenesis protein CcmI -
A8L59_RS07840 1757219..1757623 + 405 WP_064586610.1 hypothetical protein -
A8L59_RS07845 1757727..1758608 - 882 WP_064586611.1 LysR family transcriptional regulator -
A8L59_RS07850 1758833..1759045 + 213 WP_064586612.1 type II toxin-antitoxin system HicA family toxin Toxin
A8L59_RS07855 1759045..1759449 + 405 WP_064586613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A8L59_RS07860 1759518..1760705 - 1188 WP_064586614.1 MFS transporter -
A8L59_RS07865 1760949..1761569 + 621 WP_064586615.1 hypothetical protein -
A8L59_RS07870 1761666..1762664 - 999 WP_025111899.1 sulfate ABC transporter substrate-binding protein -
A8L59_RS07875 1762792..1763616 - 825 WP_064586616.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7855.99 Da        Isoelectric Point: 10.5308

>T63779 WP_064586612.1 NZ_CP015852:1758833-1759045 [Pseudomonas koreensis]
VQSRLLIKELEEAGWTLDRVSGSHHVFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLGNPPASYKGDP

Download         Length: 213 bp

>T63779 NZ_CP015852:1758833-1759045 [Pseudomonas koreensis]
GTGCAAAGCAGGCTATTGATCAAGGAGCTGGAGGAGGCGGGCTGGACGCTGGATCGAGTGTCCGGCAGTCATCATGTCTT
CACCCACCGATACAACCCGTACACGATTCCCGTCCCCCACCCGAAAAAGGATTTGCCGCTGGGGACGGTCAAAAGCATCA
GGAGGCGTGCCGGGTTGGGCAACCCGCCAGCCAGCTACAAGGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14832.80 Da        Isoelectric Point: 4.2870

>AT63779 WP_064586613.1 NZ_CP015852:1759045-1759449 [Pseudomonas koreensis]
MQYPICIEWGDDNTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEMAADGETIPMPTSAAAHRNNPEFADMGWGM
LELDVSPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT63779 NZ_CP015852:1759045-1759449 [Pseudomonas koreensis]
ATGCAATATCCGATCTGCATCGAATGGGGTGACGACAACACCGCCATCGGTATTCAGATTCCCGACATTCCCGGCGCGGT
CACGGCCGGGGATACCTTCGAGGACGCCTATAACGCAGCCGTTGAAATCGCTCACATCATGCTGCAAGAGATGGCGGCGG
ACGGCGAAACAATTCCGATGCCGACGTCGGCAGCGGCCCATCGCAATAATCCGGAGTTTGCCGACATGGGCTGGGGCATG
CTGGAGCTGGATGTTTCGCCCTATTTGGGCAAAACCGAAAAGGTCAACGTGACGTTGCCAGGCTACGTGATCCAGCGCAT
TGATCGATATGTGCGTGAGCACAATGTGAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGCT
ATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References