Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1272807..1273285 Replicon chromosome
Accession NZ_CP015846
Organism Escherichia coli O157:H7 strain FRIK2069

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A8V30_RS06525 Protein ID WP_001303876.1
Coordinates 1272807..1273094 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A8V30_RS06530 Protein ID WP_000536233.1
Coordinates 1273094..1273285 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8V30_RS06475 1267956..1270427 - 2472 WP_000034474.1 exonuclease -
A8V30_RS06480 1270521..1270712 - 192 WP_001098307.1 DUF1482 family protein -
A8V30_RS06485 1270709..1270897 - 189 WP_000413705.1 cell division inhibition protein DicB -
A8V30_RS06495 1271471..1271656 + 186 WP_001133046.1 hypothetical protein -
A8V30_RS06500 1271843..1272232 - 390 WP_000394511.1 hypothetical protein -
A8V30_RS06510 1272374..1272529 - 156 WP_000379575.1 DUF1391 family protein -
A8V30_RS06525 1272807..1273094 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8V30_RS06530 1273094..1273285 - 192 WP_000536233.1 hypothetical protein Antitoxin
A8V30_RS06535 1273313..1273714 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A8V30_RS06540 1273823..1274095 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A8V30_RS06545 1274079..1274504 + 426 WP_000693855.1 Rha family transcriptional regulator -
A8V30_RS06550 1274711..1275166 - 456 WP_000273724.1 hypothetical protein -
A8V30_RS06555 1275245..1276336 + 1092 WP_001205823.1 hypothetical protein -
A8V30_RS06560 1276343..1277089 + 747 WP_000788751.1 ATP-binding protein -
A8V30_RS06565 1277111..1277881 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T63735 WP_001303876.1 NZ_CP015846:c1273094-1272807 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T63735 NZ_CP015846:c1273094-1272807 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT63735 WP_000536233.1 NZ_CP015846:c1273285-1273094 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT63735 NZ_CP015846:c1273285-1273094 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References