Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2246320..2246791 | Replicon | chromosome |
| Accession | NZ_CP015843 | ||
| Organism | Escherichia coli O157:H7 strain FRIK2455 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | A8V32_RS12260 | Protein ID | WP_001303511.1 |
| Coordinates | 2246513..2246791 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | A8V32_RS12255 | Protein ID | WP_001302048.1 |
| Coordinates | 2246320..2246511 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A8V32_RS12215 | 2241527..2242111 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| A8V32_RS12220 | 2242168..2242563 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| A8V32_RS12225 | 2242579..2243348 | - | 770 | Protein_2215 | DUF1627 domain-containing protein | - |
| A8V32_RS12230 | 2243374..2244114 | - | 741 | WP_000788936.1 | ATP-binding protein | - |
| A8V32_RS12235 | 2244121..2245083 | - | 963 | WP_000095670.1 | helix-turn-helix domain-containing protein | - |
| A8V32_RS12240 | 2245106..2245531 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| A8V32_RS12245 | 2245528..2245830 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| A8V32_RS12250 | 2245928..2246299 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| A8V32_RS12255 | 2246320..2246511 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| A8V32_RS12260 | 2246513..2246791 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A8V32_RS12270 | 2247144..2247443 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| A8V32_RS12275 | 2247515..2247733 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| A8V32_RS12285 | 2248302..2248490 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| A8V32_RS12290 | 2248487..2248678 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| A8V32_RS12295 | 2248771..2251242 | + | 2472 | WP_000048458.1 | exonuclease | - |
| A8V32_RS12300 | 2251315..2251566 | + | 252 | WP_000005552.1 | excisionase family protein | - |
| A8V32_RS31530 | 2251601..2251785 | + | 185 | Protein_2229 | DUF3596 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2176346..2261671 | 85325 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T63702 WP_001303511.1 NZ_CP015843:2246513-2246791 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T63702 NZ_CP015843:2246513-2246791 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT63702 WP_001302048.1 NZ_CP015843:2246320-2246511 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT63702 NZ_CP015843:2246320-2246511 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|