Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 5352387..5352884 Replicon chromosome
Accession NZ_CP015842
Organism Escherichia coli O157:H7 strain FRIK2533

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag A8V31_RS28945 Protein ID WP_001173343.1
Coordinates 5352711..5352884 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag A8V31_RS28940 Protein ID WP_000398619.1
Coordinates 5352387..5352683 (+) Length 99 a.a.

Genomic Context

A8V31_RS28930A8V31_RS28935A8V31_RS28940A8V31_RS28945A8V31_RS28920A8V31_RS28925A8V31_RS28950A8V31_RS28955
Location: 5351646..5351876 (231 bp)
Type: Others
Protein ID: WP_000371704.1
Location: 5351888..5352160 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 5352387..5352683 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 5352711..5352884 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 5349118..5349837 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 5349834..5351465 (1632 bp)
Type: Others
Protein ID: WP_001216477.1
Location: 5353003..5354520 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 5354757..5356214 (1458 bp)
Type: Others
Protein ID: WP_000856824.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A8V31_RS289205349118..5349837-720WP_000611288.1two-component system response regulator DcuR-
A8V31_RS289255349834..5351465-1632WP_001216477.1sensor histidine kinase-
A8V31_RS289305351646..5351876+231WP_000371704.1(4Fe-4S)-binding protein-
A8V31_RS289355351888..5352160+273WP_000405647.1N-acetyltransferase-
A8V31_RS289405352387..5352683+297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
A8V31_RS289455352711..5352884+174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
A8V31_RS289505353003..5354520-1518WP_001295074.1lysine--tRNA ligase-
A8V31_RS289555354757..5356214-1458WP_000856824.1dipeptide/tripeptide permease DtpC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T63679 WP_001173343.1 NZ_CP015842:5352711-5352884 [Escherichia coli O157:H7]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T63679 NZ_CP015842:5352711-5352884 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT63679 WP_000398619.1 NZ_CP015842:5352387-5352683 [Escherichia coli O157:H7]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT63679 NZ_CP015842:5352387-5352683 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41

Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References