63624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4938110..4938705 Replicon chromosome
Accession NZ_CP015834
Organism Escherichia coli strain MS6198

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag MS6198_RS24295 Protein ID WP_000239581.1
Coordinates 4938355..4938705 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag MS6198_RS24290 Protein ID WP_001223213.1
Coordinates 4938110..4938361 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6198_RS24280 4933775..4937554 + 3780 WP_022646473.1 autotransporter assembly complex protein TamB -
MS6198_RS24285 4937557..4937898 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MS6198_RS24290 4938110..4938361 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MS6198_RS24295 4938355..4938705 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
MS6198_RS24300 4938784..4939314 - 531 WP_000055075.1 inorganic diphosphatase -
MS6198_RS24305 4939624..4940580 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MS6198_RS24310 4940713..4942215 + 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
MS6198_RS24315 4942229..4943251 + 1023 WP_001298067.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T63624 WP_000239581.1 NZ_CP015834:4938355-4938705 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T63624 NZ_CP015834:4938355-4938705 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT63624 WP_001223213.1 NZ_CP015834:4938110-4938361 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT63624 NZ_CP015834:4938110-4938361 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References