Detailed information of TA system TA063622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4706670..4707658
• Replicon: chromosome
• Accession: NZ_CP015834
• Organism: Escherichia coli strain MS6198

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MS6198_RS23095
• Protein ID: WP_014640052.1
• Coordinates: 4707272..4707658 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: MS6198_RS23090
• Protein ID: WP_000458584.1
• Coordinates: 4706670..4707242 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MS6198_RS23065	4701740..4702348	+	609	WP_000646078.1	transcriptional repressor LexA	-
MS6198_RS23070	4702421..4703746	+	1326	WP_001361471.1	MATE family efflux transporter DinF	-
MS6198_RS23075	4703862..4704071	+	210	WP_001296638.1	CsbD family protein	-
MS6198_RS23080	4704113..4704628	-	516	WP_000416263.1	zinc uptake transcriptional repressor Zur	-
MS6198_RS23085	4704946..4705950	+	1005	WP_022646425.1	DUF2713 family protein	-
MS6198_RS29445	4706312..4706434	+	123	WP_001382617.1	hypothetical protein	-
MS6198_RS23090	4706670..4707242	+	573	WP_000458584.1	SocA family protein	Antitoxin
MS6198_RS23095	4707272..4707658	+	387	WP_014640052.1	hypothetical protein	Toxin
MS6198_RS31540	4707698..4707871	+	174	WP_000390072.1	hypothetical protein	-
MS6198_RS23100	4707919..4708200	-	282	WP_001093918.1	pyocin activator PrtN family protein	-
MS6198_RS23105	4708237..4708809	-	573	WP_001061348.1	3'-5' exoribonuclease	-
MS6198_RS23110	4708809..4709612	-	804	WP_039052442.1	DUF551 domain-containing protein	-
MS6198_RS31545	4709616..4709765	-	150	WP_001151811.1	hypothetical protein	-
MS6198_RS23115	4709767..4710354	-	588	WP_024190088.1	hypothetical protein	-
MS6198_RS23120	4710345..4710881	-	537	WP_000008179.1	5'-deoxynucleotidase	-
MS6198_RS23125	4711009..4711833	-	825	WP_039052441.1	DUF2303 family protein	-
MS6198_RS23130	4711899..4712261	-	363	WP_039052440.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4701740..4751225	49485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T63622 WP_014640052.1 NZ_CP015834:4707272-4707658 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T63622 NZ_CP015834:4707272-4707658 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT63622 WP_000458584.1 NZ_CP015834:4706670-4707242 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT63622 NZ_CP015834:4706670-4707242 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAATT
GAGTCGTGCGGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATTTGATCTCGCAAATATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5