Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3599202..3599680 Replicon chromosome
Accession NZ_CP015832
Organism Escherichia coli O157 strain 180-PT54

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A8L39_RS19105 Protein ID WP_001303876.1
Coordinates 3599393..3599680 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A8L39_RS19100 Protein ID WP_000536233.1
Coordinates 3599202..3599393 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L39_RS19065 3594606..3595376 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A8L39_RS19070 3595398..3596144 - 747 WP_000788751.1 ATP-binding protein -
A8L39_RS19075 3596151..3597242 - 1092 WP_001205823.1 hypothetical protein -
A8L39_RS32680 3597321..3597776 + 456 WP_000273724.1 hypothetical protein -
A8L39_RS19085 3597983..3598408 - 426 WP_000693855.1 Rha family transcriptional regulator -
A8L39_RS19090 3598392..3598664 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A8L39_RS19095 3598773..3599174 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A8L39_RS19100 3599202..3599393 + 192 WP_000536233.1 hypothetical protein Antitoxin
A8L39_RS19105 3599393..3599680 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8L39_RS19110 3599958..3600113 + 156 WP_000379575.1 DUF1391 family protein -
A8L39_RS19115 3600255..3600644 + 390 WP_000394511.1 hypothetical protein -
A8L39_RS19120 3600831..3601016 - 186 WP_001133046.1 hypothetical protein -
A8L39_RS32695 3601590..3601778 + 189 WP_000413705.1 cell division inhibition protein DicB -
A8L39_RS19135 3601775..3601966 + 192 WP_001098307.1 DUF1482 family protein -
A8L39_RS19140 3602060..3604531 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T63586 WP_001303876.1 NZ_CP015832:3599393-3599680 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T63586 NZ_CP015832:3599393-3599680 [Escherichia coli O157]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT63586 WP_000536233.1 NZ_CP015832:3599202-3599393 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT63586 NZ_CP015832:3599202-3599393 [Escherichia coli O157]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References