Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3967610..3968445 Replicon chromosome
Accession NZ_CP015831
Organism Escherichia coli O157 strain 644-PT8

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag A8L40_RS21060 Protein ID WP_032107687.1
Coordinates 3967610..3967987 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A8L40_RS21065 Protein ID WP_033805992.1
Coordinates 3968077..3968445 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L40_RS21030 3964291..3964995 + 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -
A8L40_RS21035 3965280..3965498 + 219 WP_001040187.1 translation initiation factor IF-1 -
A8L40_RS21045 3965989..3966831 - 843 WP_001684189.1 DUF4942 domain-containing protein -
A8L40_RS21050 3966937..3967113 - 177 WP_001684188.1 DUF957 domain-containing protein -
A8L40_RS21055 3967125..3967613 - 489 WP_001684187.1 hypothetical protein -
A8L40_RS21060 3967610..3967987 - 378 WP_032107687.1 type IV toxin-antitoxin system toxin CbtA Toxin
A8L40_RS21065 3968077..3968445 - 369 WP_033805992.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A8L40_RS21070 3968525..3968746 - 222 WP_001684649.1 DUF987 domain-containing protein -
A8L40_RS21075 3968815..3969291 - 477 WP_001186745.1 RadC family protein -
A8L40_RS21080 3969307..3969786 - 480 WP_001684386.1 antirestriction protein -
A8L40_RS35310 3969952..3970125 - 174 WP_001684385.1 hypothetical protein -
A8L40_RS21090 3970125..3970943 - 819 WP_033805991.1 DUF945 domain-containing protein -
A8L40_RS34565 3971033..3971256 - 224 Protein_4046 DUF905 family protein -
A8L40_RS21100 3971354..3971767 - 414 WP_000789535.1 hypothetical protein -
A8L40_RS21105 3972037..3972576 - 540 WP_001104020.1 DUF4339 domain-containing protein -
A8L40_RS35315 3972701..3973158 - 458 Protein_4049 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13903.98 Da        Isoelectric Point: 7.7785

>T63548 WP_032107687.1 NZ_CP015831:c3967987-3967610 [Escherichia coli O157]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTCSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGVKQ

Download         Length: 378 bp

>T63548 NZ_CP015831:c3967987-3967610 [Escherichia coli O157]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGTGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13578.33 Da        Isoelectric Point: 6.7384

>AT63548 WP_033805992.1 NZ_CP015831:c3968445-3968077 [Escherichia coli O157]
VSDTLHETNHPDGNNNSPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSDADVYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSKTKK

Download         Length: 369 bp

>AT63548 NZ_CP015831:c3968445-3968077 [Escherichia coli O157]
GTGTCAGACACGCTCCATGAAACAAATCACCCCGACGGCAATAACAACAGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGTATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCAAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References