Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3854867..3855345 Replicon chromosome
Accession NZ_CP015831
Organism Escherichia coli O157 strain 644-PT8

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A8L40_RS20550 Protein ID WP_001303876.1
Coordinates 3855058..3855345 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A8L40_RS20545 Protein ID WP_000536233.1
Coordinates 3854867..3855058 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8L40_RS20510 3850271..3851041 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A8L40_RS20515 3851063..3851809 - 747 WP_000788751.1 ATP-binding protein -
A8L40_RS20520 3851816..3852907 - 1092 WP_001205823.1 hypothetical protein -
A8L40_RS33715 3852986..3853441 + 456 WP_000273724.1 hypothetical protein -
A8L40_RS20530 3853648..3854073 - 426 WP_000693855.1 Rha family transcriptional regulator -
A8L40_RS20535 3854057..3854329 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A8L40_RS20540 3854438..3854839 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A8L40_RS20545 3854867..3855058 + 192 WP_000536233.1 hypothetical protein Antitoxin
A8L40_RS20550 3855058..3855345 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8L40_RS20555 3855623..3855778 + 156 WP_000379575.1 DUF1391 family protein -
A8L40_RS20560 3855920..3856309 + 390 WP_000394511.1 hypothetical protein -
A8L40_RS20565 3856496..3856681 - 186 WP_001133046.1 hypothetical protein -
A8L40_RS33730 3857255..3857443 + 189 WP_000413705.1 cell division inhibition protein DicB -
A8L40_RS20580 3857440..3857631 + 192 WP_001098307.1 DUF1482 family protein -
A8L40_RS20585 3857725..3860196 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T63547 WP_001303876.1 NZ_CP015831:3855058-3855345 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T63547 NZ_CP015831:3855058-3855345 [Escherichia coli O157]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT63547 WP_000536233.1 NZ_CP015831:3854867-3855058 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT63547 NZ_CP015831:3854867-3855058 [Escherichia coli O157]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References