Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4119503..4120019 Replicon chromosome
Accession NZ_CP015822
Organism Klebsiella pneumoniae isolate blood sample

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag A8N26_RS20910 Protein ID WP_002886902.1
Coordinates 4119735..4120019 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A8N26_RS20905 Protein ID WP_002886901.1
Coordinates 4119503..4119745 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8N26_RS20890 4115532..4116272 + 741 WP_002886899.1 KDGP aldolase family protein -
A8N26_RS20895 4116338..4117492 + 1155 WP_002886900.1 lactonase family protein -
A8N26_RS20900 4117515..4119425 + 1911 WP_004152270.1 BglG family transcription antiterminator -
A8N26_RS20905 4119503..4119745 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A8N26_RS20910 4119735..4120019 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8N26_RS20915 4120023..4120487 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A8N26_RS20920 4120728..4122866 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
A8N26_RS20930 4123223..4123966 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A8N26_RS32495 4123969..4124142 - 174 WP_002886906.1 hypothetical protein -
A8N26_RS20940 4124227..4124535 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T63513 WP_002886902.1 NZ_CP015822:4119735-4120019 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T63513 NZ_CP015822:4119735-4120019 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT63513 WP_002886901.1 NZ_CP015822:4119503-4119745 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT63513 NZ_CP015822:4119503-4119745 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References