Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 862161..862638 Replicon chromosome
Accession NZ_CP015817
Organism Staphylococcus aureus strain FORC_039

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC39_RS04290 Protein ID WP_000052076.1
Coordinates 862161..862349 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC39_RS04295 Protein ID WP_001059690.1
Coordinates 862378..862638 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC39_RS04260 858196..858666 + 471 WP_000824472.1 hypothetical protein -
FORC39_RS04265 859007..859693 + 687 WP_001566557.1 thermonuclease family protein -
FORC39_RS04270 860050..860250 + 201 WP_001059082.1 cold-shock protein -
FORC39_RS04275 860745..860970 - 226 Protein_791 hypothetical protein -
FORC39_RS04280 861032..861316 - 285 WP_001004394.1 hypothetical protein -
FORC39_RS04285 861404..861973 - 570 WP_001106652.1 hypothetical protein -
FORC39_RS04290 862161..862349 - 189 WP_000052076.1 hypothetical protein Toxin
FORC39_RS04295 862378..862638 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC39_RS04300 862979..863182 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC39_RS04305 863179..863415 - 237 WP_000368687.1 hypothetical protein -
FORC39_RS04310 863640..864221 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
FORC39_RS04315 864294..864911 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FORC39_RS04320 865066..865560 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC39_RS04325 865959..866381 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC39_RS04330 866529..867245 + 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-137)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T63480 WP_000052076.1 NZ_CP015817:c862349-862161 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T63480 NZ_CP015817:c862349-862161 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT63480 WP_001059690.1 NZ_CP015817:c862638-862378 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT63480 NZ_CP015817:c862638-862378 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References