Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3697508..3698168 Replicon chromosome
Accession NZ_CP015774
Organism Lelliottia amnigena strain ZB04

Toxin (Protein)


Gene name cptA Uniprot ID A0A1A9FED4
Locus tag A8A57_RS17605 Protein ID WP_064327279.1
Coordinates 3697508..3697921 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1A9FEC5
Locus tag A8A57_RS17610 Protein ID WP_064327280.1
Coordinates 3697902..3698168 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8A57_RS17585 3693506..3695239 - 1734 WP_064327276.1 single-stranded-DNA-specific exonuclease RecJ -
A8A57_RS17590 3695245..3695958 - 714 WP_064328184.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A8A57_RS17595 3695987..3696883 - 897 WP_064327277.1 site-specific tyrosine recombinase XerD -
A8A57_RS17600 3696983..3697504 + 522 WP_064327278.1 flavodoxin FldB -
A8A57_RS17605 3697508..3697921 - 414 WP_064327279.1 protein YgfX Toxin
A8A57_RS17610 3697902..3698168 - 267 WP_064327280.1 FAD assembly factor SdhE Antitoxin
A8A57_RS17615 3698469..3699449 + 981 WP_064327281.1 tRNA-modifying protein YgfZ -
A8A57_RS17620 3699575..3700234 - 660 WP_064327282.1 hemolysin III family protein -
A8A57_RS17625 3700398..3700709 - 312 WP_064327283.1 N(4)-acetylcytidine aminohydrolase -
A8A57_RS17630 3700761..3701492 + 732 WP_064327284.1 MurR/RpiR family transcriptional regulator -
A8A57_RS17635 3701609..3703042 + 1434 WP_064327285.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16288.23 Da        Isoelectric Point: 11.7797

>T63470 WP_064327279.1 NZ_CP015774:c3697921-3697508 [Lelliottia amnigena]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRINARQGEIKLMMDSRLRWQGK
EWEIVGTPWMLKSGMMFRLRQTEGKRSQHLWLAADSMDSAEWRDLRRMLLQQPTQGR

Download         Length: 414 bp

>T63470 NZ_CP015774:c3697921-3697508 [Lelliottia amnigena]
GTGGTCCTGTGGCAATCTGATCTGCGCGTTTCCTGGCGCTCACAGTGGATGTCGTTATTGCTCCACGGTCTGGTCGCGGC
CATTGTTTTATTAATGCCATGGCCGCTGAGCTACACGCCGTTATGGCTTCTGCTCCTTTCGCTGGTGGTGTTCGACAGCG
TTCGCAGCCAACGACGCATTAACGCCCGTCAGGGTGAAATCAAGCTGATGATGGATTCTCGCCTGCGCTGGCAGGGCAAA
GAGTGGGAAATTGTCGGTACGCCGTGGATGCTCAAATCCGGCATGATGTTTCGTCTGCGGCAGACGGAAGGGAAGCGTAG
CCAGCATTTGTGGCTGGCAGCGGACAGCATGGATTCGGCAGAGTGGCGGGATTTACGTCGGATGCTGTTACAGCAACCGA
CGCAGGGGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10514.96 Da        Isoelectric Point: 5.6254

>AT63470 WP_064327280.1 NZ_CP015774:c3698168-3697902 [Lelliottia amnigena]
MDINNKARIHWACRRGMRELDISVMPFFEHEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT63470 NZ_CP015774:c3698168-3697902 [Lelliottia amnigena]
ATGGACATTAACAATAAAGCCCGCATTCATTGGGCATGCCGTCGCGGTATGCGCGAACTCGATATCTCTGTCATGCCCTT
CTTTGAGCATGAGTACGACAGCCTGAGCGATGATGACAAACGTCTGTTCGTTCGTCTGCTTGAAAGCGACGATCCTGATT
TGTTCAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9FED4

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9FEC5

References