Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 580675..581450 Replicon chromosome
Accession NZ_CP015774
Organism Lelliottia amnigena strain ZB04

Toxin (Protein)


Gene name ypjF Uniprot ID A0A1A9F770
Locus tag A8A57_RS02830 Protein ID WP_064324662.1
Coordinates 581079..581450 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1A9F7U5
Locus tag A8A57_RS02825 Protein ID WP_064324661.1
Coordinates 580675..581040 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8A57_RS02780 575972..576676 + 705 WP_064324655.1 WYL domain-containing protein -
A8A57_RS02785 576676..577245 + 570 WP_064324656.1 hypothetical protein -
A8A57_RS02790 577282..577734 + 453 WP_064324657.1 hypothetical protein -
A8A57_RS02795 577731..578180 + 450 WP_064324658.1 hypothetical protein -
A8A57_RS02800 578252..578482 + 231 WP_064324659.1 DUF905 domain-containing protein -
A8A57_RS02805 578581..579402 + 822 WP_064324660.1 DUF945 domain-containing protein -
A8A57_RS02810 579433..579876 + 444 WP_001093282.1 antirestriction protein -
A8A57_RS02815 579889..580431 + 543 WP_082904906.1 DNA repair protein RadC -
A8A57_RS02820 580428..580649 + 222 WP_063963757.1 DUF987 family protein -
A8A57_RS02825 580675..581040 + 366 WP_064324661.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A8A57_RS02830 581079..581450 + 372 WP_064324662.1 TA system toxin CbtA family protein Toxin
A8A57_RS02835 581747..582622 - 876 WP_064324663.1 HNH endonuclease -
A8A57_RS02840 582923..583396 + 474 WP_082904907.1 type I toxin-antitoxin system SymE family toxin -
A8A57_RS02845 583478..583849 - 372 WP_064324664.1 hypothetical protein -
A8A57_RS02850 583964..584212 - 249 WP_064324665.1 bacteriocin immunity protein -
A8A57_RS02855 584209..585861 - 1653 WP_064324666.1 S-type pyocin domain-containing protein -
A8A57_RS02860 585865..586347 - 483 WP_064324667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 571007..586721 15714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13716.66 Da        Isoelectric Point: 6.4803

>T63458 WP_064324662.1 NZ_CP015774:581079-581450 [Lelliottia amnigena]
MQTISSHPTRAAQPCLSPVEIWQLLLTHLLSQHYGLTLNDTPFSDEATIQEHIDAGISLSDAVNFLVEKYELVRIDCDGC
SVMEKSPFITSIDILRARKASGLMKRNSHKTVTRVTAGQHQEL

Download         Length: 372 bp

>T63458 NZ_CP015774:581079-581450 [Lelliottia amnigena]
ATGCAAACCATATCATCACACCCGACACGGGCGGCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGTTGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTGATGAAGCCACCATCCAGGAACATATTG
ATGCAGGAATATCGCTTAGCGATGCGGTAAACTTTCTTGTCGAAAAATATGAACTGGTAAGAATTGACTGCGATGGTTGC
TCTGTCATGGAGAAGTCACCGTTTATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACGCAA
CAGTCACAAAACTGTTACCAGGGTAACGGCAGGTCAACATCAGGAGCTATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13392.03 Da        Isoelectric Point: 5.4296

>AT63458 WP_064324661.1 NZ_CP015774:580675-581040 [Lelliottia amnigena]
MNNHSESGAIPENSPCQQWGLKSTITPCFGARLVQEGDRLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELMLTSGE
LNPRHPHSVTLYHNGLTCEADTLGSCGYVFIAIYPEHTEPQ

Download         Length: 366 bp

>AT63458 NZ_CP015774:580675-581040 [Lelliottia amnigena]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATTCCCCCTGCCAGCAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTGCTTTCA
GTGACGAGCATGCGTTGCGCCTCGACCAGGCCTTTCCGTTAATACTCAAGCAGCTGGAGCTGATGCTCACCAGCGGAGAG
CTCAACCCTAGGCACCCGCACAGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTTCATTGCTATCTATCCTGAGCATACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9F770

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9F7U5

References