Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3728739..3729268 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag SZ58_RS18115 Protein ID WP_003417760.1
Coordinates 3729011..3729268 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag SZ58_RS18110 Protein ID WP_003417757.1
Coordinates 3728739..3729014 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS22290 3723765..3725068 - 1304 Protein_3414 PPE domain-containing protein -
SZ58_RS22295 3725537..3726974 - 1438 Protein_3415 FAD-binding oxidoreductase -
SZ58_RS18095 3727077..3727466 + 390 WP_010950876.1 DUF732 domain-containing protein -
SZ58_RS18100 3727480..3727773 - 294 WP_003417749.1 DUF3017 domain-containing protein -
SZ58_RS18105 3727770..3728615 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
SZ58_RS18110 3728739..3729014 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
SZ58_RS18115 3729011..3729268 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
SZ58_RS18120 3729310..3730500 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
SZ58_RS18125 3730617..3730985 + 369 WP_003417765.1 FHA domain-containing protein -
SZ58_RS18130 3730982..3731533 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
SZ58_RS18135 3731540..3732121 - 582 WP_003417769.1 ATP/GTP-binding protein -
SZ58_RS18140 3732102..3732470 - 369 WP_044291535.1 DUF742 domain-containing protein -
SZ58_RS18145 3732448..3732840 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T63454 WP_003417760.1 NZ_CP015773:3729011-3729268 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T63454 NZ_CP015773:3729011-3729268 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT63454 WP_003417757.1 NZ_CP015773:3728739-3729014 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT63454 NZ_CP015773:3728739-3729014 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References