Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2387047..2387576 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag SZ58_RS11535 Protein ID WP_003411124.1
Coordinates 2387047..2387364 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag SZ58_RS11540 Protein ID WP_003411127.1
Coordinates 2387361..2387576 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS11505 2382068..2383144 + 1077 WP_003411110.1 hypothetical protein -
SZ58_RS11510 2383141..2383422 + 282 WP_003411112.1 hypothetical protein -
SZ58_RS11515 2383458..2384531 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
SZ58_RS11520 2384536..2385066 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
SZ58_RS11525 2385114..2386460 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
SZ58_RS11535 2387047..2387364 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SZ58_RS11540 2387361..2387576 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
SZ58_RS11545 2387831..2388889 + 1059 WP_003411129.1 hypothetical protein -
SZ58_RS11550 2389019..2389375 - 357 WP_003411130.1 hypothetical protein -
SZ58_RS11555 2389470..2390252 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
SZ58_RS11560 2390520..2390810 - 291 WP_003900476.1 YggT family protein -
SZ58_RS11565 2390972..2391628 - 657 WP_044290799.1 cell division protein SepF -
SZ58_RS11570 2391694..2392470 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T63438 WP_003411124.1 NZ_CP015773:c2387364-2387047 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T63438 NZ_CP015773:c2387364-2387047 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT63438 WP_003411127.1 NZ_CP015773:c2387576-2387361 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT63438 NZ_CP015773:c2387576-2387361 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References