Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2216050..2216948 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag SZ58_RS10710 Protein ID WP_003410001.1
Coordinates 2216050..2216610 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag SZ58_RS10715 Protein ID WP_003410003.1
Coordinates 2216607..2216948 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS10675 2211219..2211872 - 654 WP_003409976.1 cutinase Cfp21 -
SZ58_RS10680 2211987..2212217 + 231 WP_003409980.1 DUF167 domain-containing protein -
SZ58_RS10685 2212302..2213213 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
SZ58_RS10690 2213322..2213921 + 600 WP_003409989.1 L-lysine exporter -
SZ58_RS10695 2214337..2214765 + 429 WP_003409992.1 cellulose-binding protein -
SZ58_RS10700 2214991..2215530 + 540 WP_044291145.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
SZ58_RS10710 2216050..2216610 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
SZ58_RS10715 2216607..2216948 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
SZ58_RS10720 2217034..2217291 + 258 WP_003410006.1 hypothetical protein -
SZ58_RS10725 2217192..2217527 - 336 WP_003410009.1 dehydrogenase -
SZ58_RS10730 2217616..2217960 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
SZ58_RS10735 2217954..2218202 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
SZ58_RS10740 2218302..2220617 - 2316 WP_003899120.1 cation transporter ATPase CptG -
SZ58_RS10745 2220614..2220886 - 273 WP_003410017.1 DUF1490 family protein -
SZ58_RS10750 2220939..2221295 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T63432 WP_003410001.1 NZ_CP015773:c2216610-2216050 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T63432 NZ_CP015773:c2216610-2216050 [Mycobacterium tuberculosis variant bovis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT63432 WP_003410003.1 NZ_CP015773:c2216948-2216607 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT63432 NZ_CP015773:c2216948-2216607 [Mycobacterium tuberculosis variant bovis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References