Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2199710..2200254 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag SZ58_RS10595 Protein ID WP_003409896.1
Coordinates 2199710..2200006 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag SZ58_RS10600 Protein ID WP_003409899.1
Coordinates 2200003..2200254 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS10540 2194743..2195093 - 351 WP_003409871.1 hypothetical protein -
SZ58_RS10545 2195104..2196006 - 903 WP_003409874.1 hypothetical protein -
SZ58_RS10550 2196027..2196218 - 192 WP_003409876.1 hypothetical protein -
SZ58_RS10555 2196219..2196515 - 297 WP_003409877.1 hypothetical protein -
SZ58_RS10560 2196755..2196970 + 216 WP_003409878.1 antitoxin -
SZ58_RS10565 2196967..2197278 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
SZ58_RS21960 2197252..2197773 - 522 WP_010950637.1 hypothetical protein -
SZ58_RS10575 2197748..2198125 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
SZ58_RS10580 2198167..2198616 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
SZ58_RS10585 2198613..2199158 + 546 WP_003409891.1 SecB-like chaperone -
SZ58_RS10590 2199047..2199661 - 615 WP_003901296.1 hypothetical protein -
SZ58_RS10595 2199710..2200006 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SZ58_RS10600 2200003..2200254 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SZ58_RS10605 2200241..2200735 + 495 WP_003899099.1 hypothetical protein -
SZ58_RS10610 2200895..2201302 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
SZ58_RS10615 2201306..2201578 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SZ58_RS10620 2201611..2202831 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
SZ58_RS10635 2203730..2204035 + 306 Protein_2008 ABC transporter permease -
SZ58_RS10640 2204219..2205067 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T63430 WP_003409896.1 NZ_CP015773:c2200006-2199710 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T63430 NZ_CP015773:c2200006-2199710 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT63430 WP_003409899.1 NZ_CP015773:c2200254-2200003 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT63430 NZ_CP015773:c2200254-2200003 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References