Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1385966..1386654 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag SZ58_RS06805 Protein ID WP_003406304.1
Coordinates 1386223..1386654 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag SZ58_RS06800 Protein ID WP_003406302.1
Coordinates 1385966..1386226 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS06780 1381543..1382367 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
SZ58_RS06785 1382372..1383553 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
SZ58_RS06790 1383630..1384730 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
SZ58_RS06795 1384901..1385890 + 990 WP_003406301.1 malate dehydrogenase -
SZ58_RS06800 1385966..1386226 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
SZ58_RS06805 1386223..1386654 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
SZ58_RS06810 1386677..1388365 - 1689 WP_003910308.1 PE family protein -
SZ58_RS06820 1388545..1389405 + 861 WP_003406306.1 hypothetical protein -
SZ58_RS06825 1389486..1390316 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
SZ58_RS06830 1390373..1390666 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
SZ58_RS06835 1390663..1390932 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-142)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T63420 WP_003406304.1 NZ_CP015773:1386223-1386654 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T63420 NZ_CP015773:1386223-1386654 [Mycobacterium tuberculosis variant bovis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT63420 WP_003406302.1 NZ_CP015773:1385966-1386226 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT63420 NZ_CP015773:1385966-1386226 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THR7


Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References