Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 696140..696786 Replicon chromosome
Accession NZ_CP015773
Organism Mycobacterium tuberculosis variant bovis strain SP38

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag SZ58_RS03175 Protein ID WP_003403122.1
Coordinates 696140..696532 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag SZ58_RS03180 Protein ID WP_003403125.1
Coordinates 696529..696786 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SZ58_RS03160 691801..693237 + 1437 WP_003900182.1 virulence factor Mce family protein -
SZ58_RS21915 693391..694533 + 1143 Protein_613 virulence factor Mce family protein -
SZ58_RS03170 694538..696088 + 1551 WP_003403119.1 MCE family protein -
SZ58_RS03175 696140..696532 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
SZ58_RS03180 696529..696786 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
SZ58_RS03185 696969..698204 - 1236 WP_003403128.1 ATP-binding protein -
SZ58_RS03190 698455..698868 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
SZ58_RS03195 698865..699101 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SZ58_RS03200 699205..699711 - 507 WP_003900973.1 two component system sensor kinase HK1 -
SZ58_RS03205 699825..700355 - 531 WP_003917320.1 two component system sensor kinase HK2 -
SZ58_RS03210 700339..701034 - 696 WP_197044064.1 response regulator transcription factor -
SZ58_RS03215 701157..701468 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T63404 WP_003403122.1 NZ_CP015773:c696532-696140 [Mycobacterium tuberculosis variant bovis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T63404 NZ_CP015773:c696532-696140 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT63404 WP_003403125.1 NZ_CP015773:c696786-696529 [Mycobacterium tuberculosis variant bovis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT63404 NZ_CP015773:c696786-696529 [Mycobacterium tuberculosis variant bovis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References