Detailed information of TA system TA063366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3271331..3271847
• Replicon: chromosome
• Accession: NZ_CP015753
• Organism: Klebsiella pneumoniae strain W14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: R4YAY3
• Locus tag: A7321_RS16200
• Protein ID: WP_004178374.1
• Coordinates: 3271563..3271847 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A7321_RS16195
• Protein ID: WP_064081307.1
• Coordinates: 3271331..3271573 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7321_RS16180	3267359..3268099	+	741	WP_002886899.1	KDGP aldolase family protein	-
A7321_RS16185	3268166..3269320	+	1155	WP_019704690.1	lactonase family protein	-
A7321_RS16190	3269343..3271253	+	1911	WP_009486549.1	BglG family transcription antiterminator	-
A7321_RS16195	3271331..3271573	+	243	WP_064081307.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
A7321_RS16200	3271563..3271847	+	285	WP_004178374.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7321_RS16205	3271851..3272315	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
A7321_RS16210	3272623..3274761	-	2139	WP_004222153.1	anaerobic ribonucleoside-triphosphate reductase	-
A7321_RS16220	3275118..3275861	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
A7321_RS29430	3275864..3276037	-	174	WP_032416265.1	hypothetical protein	-
A7321_RS16230	3276122..3276430	+	309	WP_002886907.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11155.97 Da
• Isoelectric Point: 10.3787

>T63366 WP_004178374.1 NZ_CP015753:3271563-3271847 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T63366 NZ_CP015753:3271563-3271847 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9076.56 Da
• Isoelectric Point: 6.3340

>AT63366 WP_064081307.1 NZ_CP015753:3271331-3271573 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTQTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT63366 NZ_CP015753:3271331-3271573 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACA
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A6THG1