Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1935485..1936142 Replicon chromosome
Accession NZ_CP015753
Organism Klebsiella pneumoniae strain W14

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A7321_RS09520 Protein ID WP_002916310.1
Coordinates 1935485..1935895 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A7321_RS09525 Protein ID WP_002916312.1
Coordinates 1935876..1936142 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7321_RS09500 1931485..1933218 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
A7321_RS09505 1933224..1933937 - 714 WP_040223689.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7321_RS09510 1933960..1934856 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A7321_RS09515 1934957..1935478 + 522 WP_004144730.1 flavodoxin FldB -
A7321_RS09520 1935485..1935895 - 411 WP_002916310.1 protein YgfX Toxin
A7321_RS09525 1935876..1936142 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A7321_RS09530 1936388..1937371 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
A7321_RS09535 1937522..1938181 - 660 WP_002916317.1 hemolysin III family protein -
A7321_RS09540 1938345..1938656 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
A7321_RS09545 1938706..1939434 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A7321_RS09550 1939553..1940986 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T63363 WP_002916310.1 NZ_CP015753:c1935895-1935485 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T63363 NZ_CP015753:c1935895-1935485 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT63363 WP_002916312.1 NZ_CP015753:c1936142-1935876 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT63363 NZ_CP015753:c1936142-1935876 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References