Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3206934..3207561 Replicon chromosome
Accession NZ_CP015750
Organism Pectobacterium wasabiae CFBP 3304

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag A7983_RS14475 Protein ID WP_005976087.1
Coordinates 3206934..3207137 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag A7983_RS14480 Protein ID WP_005976089.1
Coordinates 3207193..3207561 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7983_RS14445 3202431..3202769 + 339 WP_002208627.1 P-II family nitrogen regulator -
A7983_RS14450 3202809..3204095 + 1287 WP_005976078.1 ammonium transporter AmtB -
A7983_RS14455 3204208..3205071 - 864 WP_005976080.1 acyl-CoA thioesterase II -
A7983_RS14460 3205284..3205868 + 585 WP_005976083.1 YbaY family lipoprotein -
A7983_RS14465 3205888..3206208 - 321 WP_005976085.1 MGMT family protein -
A7983_RS14475 3206934..3207137 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
A7983_RS14480 3207193..3207561 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
A7983_RS14485 3208321..3208464 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
A7983_RS14490 3208482..3208730 - 249 WP_005976093.1 type B 50S ribosomal protein L31 -
A7983_RS14495 3208966..3212094 - 3129 WP_005976095.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T63353 WP_005976087.1 NZ_CP015750:c3207137-3206934 [Pectobacterium wasabiae CFBP 3304]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T63353 NZ_CP015750:c3207137-3206934 [Pectobacterium wasabiae CFBP 3304]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGTTAACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT63353 WP_005976089.1 NZ_CP015750:c3207561-3207193 [Pectobacterium wasabiae CFBP 3304]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT63353 NZ_CP015750:c3207561-3207193 [Pectobacterium wasabiae CFBP 3304]
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACGACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References