Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2590166..2590826 Replicon chromosome
Accession NZ_CP015750
Organism Pectobacterium wasabiae CFBP 3304

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T3W229
Locus tag A7983_RS11775 Protein ID WP_039477900.1
Coordinates 2590413..2590826 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag A7983_RS11770 Protein ID WP_005971623.1
Coordinates 2590166..2590432 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7983_RS11755 2587205..2587813 - 609 WP_005971614.1 HD domain-containing protein -
A7983_RS11760 2588222..2588869 + 648 WP_005971615.1 hemolysin III family protein -
A7983_RS11765 2588937..2589938 - 1002 WP_005971619.1 tRNA-modifying protein YgfZ -
A7983_RS11770 2590166..2590432 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
A7983_RS11775 2590413..2590826 + 414 WP_039477900.1 protein YgfX Toxin
A7983_RS11780 2591051..2591986 + 936 WP_005971629.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
A7983_RS11785 2592036..2592359 - 324 WP_005971631.1 hypothetical protein -
A7983_RS11790 2592388..2592906 - 519 WP_005971633.1 flavodoxin FldB -
A7983_RS11795 2593234..2594250 + 1017 WP_005971635.1 methionine ABC transporter ATP-binding protein -
A7983_RS11800 2594243..2594911 + 669 WP_005971637.1 ABC transporter permease -
A7983_RS11805 2594929..2595747 + 819 WP_039478006.1 methionine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16232.13 Da        Isoelectric Point: 10.2792

>T63352 WP_039477900.1 NZ_CP015750:2590413-2590826 [Pectobacterium wasabiae CFBP 3304]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLALQSADGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T63352 NZ_CP015750:2590413-2590826 [Pectobacterium wasabiae CFBP 3304]
GTGGCCCAGTGGCAATGTGACCTTCGCGTGTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGCCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTTACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACCCTGCTCAGCGAAACGACCCTAAACTGGCGGCAGCAG
GAGTGGCAGATTGTCAAACGACCGTGGTTGCTGAAAAATGGCGTGTTATTGGCATTGCAATCGGCTGATGGGAAAGACAA
GCAACAACTATGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT63352 WP_005971623.1 NZ_CP015750:2590166-2590432 [Pectobacterium wasabiae CFBP 3304]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT63352 NZ_CP015750:2590166-2590432 [Pectobacterium wasabiae CFBP 3304]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATACAGATAAGCGCACGTTTGTACGTCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3W229

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References