Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2260381..2260906 Replicon chromosome
Accession NZ_CP015750
Organism Pectobacterium wasabiae CFBP 3304

Toxin (Protein)


Gene name relE Uniprot ID A0A1D7Z1B4
Locus tag A7983_RS10275 Protein ID WP_005973612.1
Coordinates 2260622..2260906 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C6D956
Locus tag A7983_RS10270 Protein ID WP_005973616.1
Coordinates 2260381..2260632 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7983_RS10230 2255385..2255609 + 225 WP_005973635.1 hypothetical protein -
A7983_RS23900 2255618..2256007 + 390 Protein_2017 ash family protein -
A7983_RS23905 2255971..2256168 + 198 WP_005973632.1 host cell division inhibitor Icd-like protein -
A7983_RS10240 2256161..2256355 + 195 WP_005973630.1 hypothetical protein -
A7983_RS10245 2256352..2256618 + 267 WP_005973627.1 hypothetical protein -
A7983_RS10250 2256615..2256956 + 342 WP_005973624.1 DUF5375 family protein -
A7983_RS10255 2256967..2259294 + 2328 WP_005973622.1 toprim domain-containing protein -
A7983_RS10260 2259348..2259827 - 480 WP_005973620.1 GNAT family N-acetyltransferase -
A7983_RS10265 2259818..2260090 - 273 WP_005973618.1 DUF1778 domain-containing protein -
A7983_RS10270 2260381..2260632 + 252 WP_005973616.1 prevent-host-death protein Antitoxin
A7983_RS10275 2260622..2260906 + 285 WP_005973612.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A7983_RS10280 2261521..2262774 + 1254 WP_005973610.1 tyrosine-type recombinase/integrase -
A7983_RS10295 2264108..2265340 + 1233 WP_005971243.1 hypothetical protein -
A7983_RS10300 2265549..2265833 - 285 WP_005971242.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2248984..2281587 32603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11010.96 Da        Isoelectric Point: 10.1716

>T63350 WP_005973612.1 NZ_CP015750:2260622-2260906 [Pectobacterium wasabiae CFBP 3304]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKTAKDRL

Download         Length: 285 bp

>T63350 NZ_CP015750:2260622-2260906 [Pectobacterium wasabiae CFBP 3304]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCGCCCGTGCGGGAGCAGTTCAC
CAAAAAGTTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGTTAGTGTATCAAGTACTTGAGCATGAGATCGTGGTGCTGGTTTTAGCTGTGGGCAAA
CGGGAACGCTCAGAAGTTTATAAAACAGCGAAAGACCGACTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9079.35 Da        Isoelectric Point: 5.0807

>AT63350 WP_005973616.1 NZ_CP015750:2260381-2260632 [Pectobacterium wasabiae CFBP 3304]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Download         Length: 252 bp

>AT63350 NZ_CP015750:2260381-2260632 [Pectobacterium wasabiae CFBP 3304]
ATGTCCGTACAACCTATCCTTGCGAATGCTGCCGTAAGTATCAGCGACTTTAAAAAATCGCCCAATGCCGCGCTTAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGCTCACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGATTATCAGGAAGATATCGAACTTGCCAAAATCGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z1B4

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4JQP6

References