Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1798833..1799386 Replicon chromosome
Accession NZ_CP015750
Organism Pectobacterium wasabiae CFBP 3304

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1D7YZY3
Locus tag A7983_RS08035 Protein ID WP_005968205.1
Coordinates 1799072..1799386 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D7Z004
Locus tag A7983_RS08030 Protein ID WP_005968207.1
Coordinates 1798833..1799069 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7983_RS08010 1793989..1795494 + 1506 WP_005968214.1 inorganic phosphate transporter PitA -
A7983_RS08015 1795587..1795922 - 336 WP_005968212.1 universal stress protein UspB -
A7983_RS08020 1796465..1796902 + 438 WP_005968210.1 universal stress protein UspA -
A7983_RS08025 1797195..1798538 + 1344 WP_005968208.1 NADP-specific glutamate dehydrogenase -
A7983_RS08030 1798833..1799069 + 237 WP_005968207.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
A7983_RS08035 1799072..1799386 + 315 WP_005968205.1 CcdB family protein Toxin
A7983_RS08045 1799683..1801578 - 1896 WP_039478889.1 5'-nucleotidase C-terminal domain-containing protein -
A7983_RS08050 1801730..1802476 - 747 WP_005968201.1 16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11544.51 Da        Isoelectric Point: 5.7756

>T63346 WP_005968205.1 NZ_CP015750:1799072-1799386 [Pectobacterium wasabiae CFBP 3304]
MQFTVYSNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPVCSLG
AVFCDASLYRTQIKAAIDFLLDGI

Download         Length: 315 bp

>T63346 NZ_CP015750:1799072-1799386 [Pectobacterium wasabiae CFBP 3304]
ATGCAGTTCACTGTATACAGCAACACCGGGAAGAGCGCCGTCTATCCCCTGCTGCTTGATGTAACCAGCGATATTATCGG
CCAACTGAACCGCAGGATTGTGATCCCCCTGCTGCCTGTTGAAAAGTACCCAGGCAGCACGCGTCCCGAGCGGTTGGTTC
CGCTTGTCAGACTGACCGACGATAAAGAATATGCAGTTATGACGCATGAGATGGCGAGCATTCCCGTTTGTTCTCTGGGG
GCGGTGTTCTGCGATGCGTCCCTTTATCGTACTCAGATCAAAGCCGCGATTGATTTTCTTCTCGACGGTATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8923.88 Da        Isoelectric Point: 5.1147

>AT63346 WP_005968207.1 NZ_CP015750:1798833-1799069 [Pectobacterium wasabiae CFBP 3304]
MAKTQRATQSVTMTVERSLLSRAREAGINLSATLTAALDAELRQYEAKKWQEENSEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT63346 NZ_CP015750:1798833-1799069 [Pectobacterium wasabiae CFBP 3304]
ATGGCTAAAACACAACGAGCAACGCAAAGCGTTACCATGACCGTAGAACGATCCTTACTCAGCCGTGCGCGTGAGGCTGG
AATTAATCTCAGTGCCACCCTGACCGCAGCCCTTGATGCTGAACTACGCCAGTACGAAGCGAAAAAGTGGCAGGAGGAAA
ATAGCGAAGCGCTGGAAGCGCTTAACCGGTTTCACGATGAACACGGTTGTTTCAGCGATGAGTACAGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7YZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z004

References