Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3238241..3238901 Replicon chromosome
Accession NZ_CP015749
Organism Pectobacterium parmentieri strain RNS 08-42-1A

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag A8F97_RS14685 Protein ID WP_012822581.1
Coordinates 3238241..3238654 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag A8F97_RS14690 Protein ID WP_012822580.1
Coordinates 3238635..3238901 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8F97_RS14655 3233282..3234100 - 819 WP_033071942.1 MetQ/NlpA family ABC transporter substrate-binding protein -
A8F97_RS14660 3234118..3234786 - 669 WP_012822586.1 ABC transporter permease -
A8F97_RS14665 3234779..3235795 - 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
A8F97_RS14670 3236123..3236641 + 519 WP_033070904.1 flavodoxin FldB -
A8F97_RS14675 3236670..3236993 + 324 WP_012822583.1 hypothetical protein -
A8F97_RS14680 3237080..3238015 - 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
A8F97_RS14685 3238241..3238654 - 414 WP_012822581.1 protein YgfX Toxin
A8F97_RS14690 3238635..3238901 - 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
A8F97_RS14695 3239129..3240130 + 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
A8F97_RS14700 3240185..3240832 - 648 WP_012822578.1 hemolysin III family protein -
A8F97_RS14705 3241241..3241849 + 609 WP_014698756.1 HD domain-containing protein -
A8F97_RS14710 3241903..3242907 + 1005 WP_012822576.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T63338 WP_012822581.1 NZ_CP015749:c3238654-3238241 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T63338 NZ_CP015749:c3238654-3238241 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTTAGCGAAACGACCTTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT63338 WP_012822580.1 NZ_CP015749:c3238901-3238635 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT63338 NZ_CP015749:c3238901-3238635 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References