Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1676368..1678063 Replicon chromosome
Accession NZ_CP015736
Organism Shinella sp. HZN7

Toxin (Protein)


Gene name mosT Uniprot ID A0A1A9G134
Locus tag shn_RS08115 Protein ID WP_064329949.1
Coordinates 1677146..1678063 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1A9FZA2
Locus tag shn_RS08110 Protein ID WP_064329948.1
Coordinates 1676368..1677159 (+) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
shn_RS08080 1671397..1672140 + 744 Protein_1611 recombinase family protein -
shn_RS08090 1672211..1673430 + 1220 WP_145925838.1 IS3 family transposase -
shn_RS08095 1673522..1674214 + 693 WP_206362201.1 hypothetical protein -
shn_RS08100 1674244..1675116 + 873 WP_145926002.1 ParB N-terminal domain-containing protein -
shn_RS08105 1675109..1676044 + 936 WP_064329947.1 ParB N-terminal domain-containing protein -
shn_RS08110 1676368..1677159 + 792 WP_064329948.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
shn_RS08115 1677146..1678063 + 918 WP_064329949.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
shn_RS08120 1678222..1679154 + 933 WP_064329950.1 HNH endonuclease -
shn_RS08125 1679194..1680120 + 927 WP_064329951.1 HNH endonuclease -
shn_RS36775 1680364..1681308 + 945 WP_064329952.1 hypothetical protein -
shn_RS08135 1681283..1681465 - 183 Protein_1621 hypothetical protein -
shn_RS08140 1681570..1681887 + 318 Protein_1622 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-275)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(6-101)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 33707.86 Da        Isoelectric Point: 6.0659

>T63328 WP_064329949.1 NZ_CP015736:1677146-1678063 [Shinella sp. HZN7]
MPASEAYRAQVSLLVRVLPLVAEENVFALKGGTAINLFVRNLPRLSVDIDLTYLPVEDRATSLANIDAAIRRIAARIAEN
VPRSRTQAVPLHSEGAATKVLVASDGVQIKIEVTPVIRGCVYSPETRAVCDRVEELFGYAEVPVVSFPDLYAGKIVAALD
RQHPRDLFDVRDLLANEGISDELRRAFIVYILSHNRPMGEVLAPTRKDLRHEFDAGFAGMTEEPVTLEALYDAREALIAE
VVGKMPAEHRRFLLSFKAGEPDWDLLGVPGAADLPAVRWKIDNLAKLSEGRREKLLSNLRRVLAT

Download         Length: 918 bp

>T63328 NZ_CP015736:1677146-1678063 [Shinella sp. HZN7]
ATGCCGGCGTCTGAAGCCTATCGCGCGCAAGTCAGTCTCCTCGTTCGGGTTCTGCCGCTTGTTGCAGAGGAGAACGTCTT
TGCGTTGAAGGGCGGCACGGCCATCAATCTCTTCGTCAGAAACCTTCCACGCCTGTCGGTCGATATCGATCTGACCTATC
TGCCGGTCGAGGATCGCGCGACGTCCCTCGCCAATATCGATGCCGCCATACGACGGATTGCTGCTCGAATAGCCGAGAAT
GTACCGCGTAGCCGCACCCAGGCCGTGCCGTTGCACAGCGAAGGCGCTGCAACAAAGGTGCTGGTTGCCTCCGACGGCGT
GCAGATCAAAATCGAGGTGACGCCCGTCATTCGTGGCTGCGTCTACTCTCCGGAGACACGGGCGGTTTGCGACCGGGTTG
AAGAGCTCTTCGGATATGCCGAGGTGCCCGTTGTGTCCTTCCCGGACCTCTATGCCGGCAAGATCGTCGCCGCCTTGGAT
CGGCAGCATCCGCGAGATTTGTTCGATGTCAGGGATCTGCTCGCGAATGAGGGAATATCCGATGAGCTGCGGCGTGCCTT
CATTGTCTACATTCTAAGCCACAACAGGCCGATGGGCGAGGTCTTGGCGCCGACGCGCAAGGATTTGCGCCACGAGTTTG
ACGCGGGGTTTGCCGGCATGACGGAAGAGCCCGTGACCCTCGAGGCGTTGTACGATGCTCGTGAAGCTTTAATCGCCGAG
GTCGTTGGCAAGATGCCTGCCGAGCACCGGCGCTTTCTTCTCTCCTTCAAGGCCGGCGAGCCAGATTGGGACTTGCTTGG
CGTGCCTGGAGCCGCGGACTTGCCGGCGGTGCGCTGGAAGATCGACAACTTGGCCAAACTTTCGGAGGGCCGACGCGAAA
AGCTACTGTCTAATCTCAGGCGGGTGCTCGCGACATGA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30230.80 Da        Isoelectric Point: 9.8655

>AT63328 WP_064329948.1 NZ_CP015736:1676368-1677159 [Shinella sp. HZN7]
MVGQKNEKINQLHRLLPEGLVVDTAWLEKHGYRRQWREKYVAQGWLEGVVRGVYQRPTGNVDQAIAWQRVIISLQRLLDK
SVHVGGRSALELQGLTHYLRFSGKPEIHLYAYGSLPGWVERIPTDAQFVEHKAEKLFDADAPGRTRIVWGHWGWELDVSA
PERALCELLDLLPSRETFHQADVLMESVRTLSPKRVQAVLEACRSVKVKRLFLWFAERHAHPWFGRLDLKRIDLGHGKRQ
IVVGGRLDSKYQITVPETLDAGV

Download         Length: 792 bp

>AT63328 NZ_CP015736:1676368-1677159 [Shinella sp. HZN7]
ATGGTAGGTCAAAAAAACGAAAAGATAAACCAACTTCATCGCCTGCTCCCCGAGGGGCTGGTGGTTGACACCGCTTGGCT
GGAAAAACACGGATACCGTCGGCAGTGGCGCGAAAAATACGTAGCGCAAGGCTGGCTCGAAGGTGTCGTTCGTGGCGTCT
ATCAGCGACCGACCGGCAACGTTGATCAGGCGATAGCCTGGCAGCGCGTGATCATCTCGCTCCAGCGACTTCTGGACAAA
TCCGTGCACGTGGGCGGCCGCAGTGCCCTCGAGCTACAAGGCCTGACGCACTACCTCCGCTTTTCTGGCAAGCCAGAAAT
CCACCTCTATGCCTATGGCAGTCTGCCTGGCTGGGTCGAGCGGATACCGACCGACGCTCAGTTCGTCGAACACAAGGCAG
AGAAGCTCTTCGATGCCGACGCACCTGGAAGGACACGCATCGTGTGGGGACATTGGGGATGGGAGCTCGATGTCTCCGCG
CCCGAGCGCGCGCTTTGCGAACTTCTTGACCTGCTCCCGTCCCGGGAGACGTTCCATCAGGCCGACGTCCTAATGGAGTC
GGTCCGCACACTGAGCCCGAAGCGGGTTCAGGCCGTGCTGGAAGCGTGCCGCAGCGTAAAGGTGAAGCGGCTGTTTCTCT
GGTTCGCCGAGCGGCACGCCCATCCATGGTTCGGCCGGCTCGATCTCAAACGTATCGACCTCGGTCATGGCAAGCGTCAG
ATCGTGGTCGGCGGTCGACTGGACAGCAAGTATCAGATCACTGTGCCGGAGACACTCGATGCCGGCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9G134

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9FZA2

References