Detailed information of TA system TA063323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1984395..1984894
• Replicon: chromosome
• Accession: NZ_CP015731
• Organism: Exiguobacterium sp. U13-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ESP131_RS10250
• Protein ID: WP_069940639.1
• Coordinates: 1984395..1984673 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ESP131_RS10255
• Protein ID: WP_069940640.1
• Coordinates: 1984670..1984894 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESP131_RS16540	1979863..1980189	+	327	WP_071908772.1	four-helix bundle copper-binding protein	-
ESP131_RS10235	1980509..1981189	+	681	WP_047394277.1	response regulator transcription factor	-
ESP131_RS10240	1981227..1981652	-	426	WP_143013655.1	hypothetical protein	-
ESP131_RS10245	1982163..1984169	+	2007	WP_069940638.1	copper-translocating P-type ATPase	-
ESP131_RS10250	1984395..1984673	-	279	WP_069940639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ESP131_RS10255	1984670..1984894	-	225	WP_069940640.1	ribbon-helix-helix protein, CopG family	Antitoxin
ESP131_RS10260	1985115..1985450	-	336	WP_069940641.1	YolD-like family protein	-
ESP131_RS10265	1985629..1986180	-	552	Protein_1972	hypothetical protein	-
ESP131_RS10275	1986508..1986828	+	321	WP_069940643.1	hypothetical protein	-
ESP131_RS10280	1986832..1987122	+	291	WP_069940644.1	addiction module toxin RelE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10794.38 Da
• Isoelectric Point: 10.1915

>T63323 WP_069940639.1 NZ_CP015731:c1984673-1984395 [Exiguobacterium sp. U13-1]
MTAYTVEFERGAQKSLKKMDPQQARIIMSWIKNNLVGTDDPRRHGRGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYKYGS

Nucleotide

• Length: 279 bp

>T63323 NZ_CP015731:c1984673-1984395 [Exiguobacterium sp. U13-1]
ATGACAGCATATACGGTGGAGTTTGAGCGCGGAGCCCAAAAGTCTCTCAAGAAGATGGATCCCCAACAAGCGCGGATTAT
CATGTCCTGGATCAAGAATAATCTGGTCGGAACGGATGATCCGCGTCGTCATGGTAGAGGGCTCGTCTCGAACAGATCGG
GTGAATGGCGTTATCGCATTGGCGACTATCGTCTTATTGCTGACATCCAGGATGAAAAAGTCGTGATCTTGATTCTTGAA
ATTGGACATCGTCGTGATATCTATAAATATGGCAGTTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8541.73 Da
• Isoelectric Point: 4.6290

>AT63323 WP_069940640.1 NZ_CP015731:c1984894-1984670 [Exiguobacterium sp. U13-1]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFGDMMKELDLE

Nucleotide

• Length: 225 bp

>AT63323 NZ_CP015731:c1984894-1984670 [Exiguobacterium sp. U13-1]
ATGAGTACCATTTCCGTACGTCTGGATGATCAGGATACACGACTCATCAAGGAATATGCGAAAGCAAAGAACATCACGAT
TTCTACACTCGTTCGCGATGCTGTCCTCGACCGCATCGAAGACGAAATCGATTTGCAACTCTATCATGATTCGATGGCAG
CACACCGTAAAAAATCAGAAGCGATCTCTTTCGGCGATATGATGAAGGAACTTGATTTAGAATGA