Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1964929..1965419 Replicon chromosome
Accession NZ_CP015731
Organism Exiguobacterium sp. U13-1

Toxin (Protein)


Gene name relE Uniprot ID A0A0V8GBT6
Locus tag ESP131_RS10155 Protein ID WP_058266059.1
Coordinates 1964929..1965198 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A031ILR5
Locus tag ESP131_RS10160 Protein ID WP_026829710.1
Coordinates 1965195..1965419 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESP131_RS10135 1959948..1960250 + 303 WP_064300933.1 DUF2089 family protein -
ESP131_RS10140 1960247..1960531 + 285 WP_050677872.1 hypothetical protein -
ESP131_RS10145 1960647..1963868 - 3222 WP_069940628.1 ABC transporter permease -
ESP131_RS10150 1963861..1964556 - 696 WP_069940629.1 ABC transporter ATP-binding protein -
ESP131_RS10155 1964929..1965198 - 270 WP_058266059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ESP131_RS10160 1965195..1965419 - 225 WP_026829710.1 ribbon-helix-helix protein, CopG family Antitoxin
ESP131_RS10165 1965617..1966708 - 1092 WP_069940630.1 hypothetical protein -
ESP131_RS10170 1966830..1967189 - 360 WP_069940631.1 copper resistance protein CopC -
ESP131_RS10175 1967396..1967716 + 321 WP_069941043.1 metalloregulator ArsR/SmtB family transcription factor -
ESP131_RS10180 1967719..1969257 + 1539 WP_083254800.1 cation transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10501.14 Da        Isoelectric Point: 10.4460

>T63322 WP_058266059.1 NZ_CP015731:c1965198-1964929 [Exiguobacterium sp. U13-1]
MTAYTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGRGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Download         Length: 270 bp

>T63322 NZ_CP015731:c1965198-1964929 [Exiguobacterium sp. U13-1]
ATGACAGCATATACGGTAGAGTTTGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGACCCTCAACAAGCGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGTAGAGGGCTCGTCTCGAACAGATCGG
GTGAATGGCGTTATCGCATCGGTGATTATCGTCTGATTGCTGACATCCAGGATGAAAAAGTCGTGATCTTAATTCTCGAA
ATAGGACACCGTCGAGATATTTACAAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8599.76 Da        Isoelectric Point: 4.5010

>AT63322 WP_026829710.1 NZ_CP015731:c1965419-1965195 [Exiguobacterium sp. U13-1]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFDDMMKELDLE

Download         Length: 225 bp

>AT63322 NZ_CP015731:c1965419-1965195 [Exiguobacterium sp. U13-1]
ATGAGTACCATTTCCGTACGTCTAGATGATCAAGATACACGACTCATCAAGGAATATGCGAAAGCGAAGAACATCACGAT
TTCTACACTCGTTCGCGATGCCGTCCTCGACCGTATCGAAGATGAAATCGATTTACAACTCTATCATGATTCGATGGCAG
CACACCGTAAAAAATCAGAAGCGATCTCTTTCGACGATATGATGAAAGAACTTGATTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8GBT6

Antitoxin

Source ID Structure
AlphaFold DB A0A031ILR5

References