Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5449024..5449658 Replicon chromosome
Accession NZ_CP015726
Organism Streptomyces sp. RTd22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A7B19_RS22500 Protein ID WP_063730354.1
Coordinates 5449236..5449658 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A7B19_RS22495 Protein ID WP_063730346.1
Coordinates 5449024..5449239 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7B19_RS22485 5446878..5448133 + 1256 Protein_4565 helix-turn-helix transcriptional regulator -
A7B19_RS22490 5448152..5448628 + 477 WP_063730335.1 hypothetical protein -
A7B19_RS22495 5449024..5449239 + 216 WP_063730346.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
A7B19_RS22500 5449236..5449658 + 423 WP_063730354.1 PIN domain nuclease Toxin
A7B19_RS22505 5449931..5450656 - 726 WP_063730357.1 hypothetical protein -
A7B19_RS22510 5450752..5451705 - 954 WP_064273790.1 DMT family transporter -
A7B19_RS22515 5451756..5452360 - 605 Protein_4571 TetR/AcrR family transcriptional regulator -
A7B19_RS22520 5452401..5452928 - 528 WP_063730363.1 hypothetical protein -
A7B19_RS22525 5453077..5454576 + 1500 WP_079151953.1 transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15421.35 Da        Isoelectric Point: 5.1653

>T63319 WP_063730354.1 NZ_CP015726:5449236-5449658 [Streptomyces sp. RTd22]
VNAAQFLIDTSALARFMRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRAHGIEDMRLMFGRVLVDDRAYDRAW
QVQEALTKQGKHRSAGPVDLVVAATAELQGLTLLHRDHDFECIAAVTGQALQWYGPEHGK

Download         Length: 423 bp

>T63319 NZ_CP015726:5449236-5449658 [Streptomyces sp. RTd22]
GTGAACGCGGCCCAGTTCCTGATCGACACCAGCGCGCTCGCGCGGTTCATGCGCGGGGACGCGGAGCAGTACGGCTGGGA
CCAGGCCGCCGCGGCTGGACTCATCGCGACCTGCCCCATTACCGAGCTTGAGTTCTTCTACAGCGCACGGTCGGCCGCTG
ACCGGGCACACGGCATCGAGGACATGCGGCTGATGTTCGGCAGGGTTCTCGTCGACGACCGCGCCTACGACCGCGCCTGG
CAGGTCCAGGAAGCCCTCACCAAGCAGGGGAAACACCGAAGTGCCGGACCAGTCGATCTGGTCGTCGCCGCGACCGCTGA
GCTGCAGGGGCTCACCCTGCTCCATCGCGATCACGACTTCGAGTGCATCGCCGCAGTGACCGGGCAAGCCCTCCAGTGGT
ATGGCCCGGAGCACGGCAAGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7862.91 Da        Isoelectric Point: 8.6595

>AT63319 WP_063730346.1 NZ_CP015726:5449024-5449239 [Streptomyces sp. RTd22]
MSRTVIDLDDDLVADVAKALGTNTKKETVNTALREVLESRRRALALARLRAAAGDGAFDLELFENKGNYRR

Download         Length: 216 bp

>AT63319 NZ_CP015726:5449024-5449239 [Streptomyces sp. RTd22]
ATGAGCCGGACGGTTATCGACCTGGACGACGACCTGGTCGCGGACGTGGCGAAGGCCCTCGGGACGAACACCAAGAAGGA
GACCGTCAACACCGCTCTTCGCGAGGTGTTGGAGAGCCGGCGTCGCGCCCTGGCTCTCGCCCGGCTGCGGGCCGCGGCGG
GCGACGGCGCATTTGATCTGGAGCTGTTCGAGAACAAGGGGAACTACCGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References