Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2232187..2232701 Replicon chromosome
Accession NZ_CP015646
Organism Staphylococcus aureus strain 08-02300

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag A7327_RS11155 Protein ID WP_000581793.1
Coordinates 2232187..2232396 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag A7327_RS11160 Protein ID WP_000138932.1
Coordinates 2232408..2232701 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7327_RS11135 2227696..2229054 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
A7327_RS11140 2229069..2230139 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
A7327_RS11145 2230457..2231659 + 1203 WP_001109939.1 rod shape-determining protein RodA -
A7327_RS11150 2231922..2232059 - 138 WP_000828354.1 hypothetical protein -
A7327_RS11155 2232187..2232396 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
A7327_RS11160 2232408..2232701 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
A7327_RS11165 2232867..2234351 + 1485 WP_000571552.1 cardiolipin synthase -
A7327_RS11170 2234379..2235026 + 648 WP_001187627.1 HD domain-containing protein -
A7327_RS11180 2235738..2236610 - 873 WP_000725802.1 membrane protein insertase YidC -
A7327_RS11185 2236696..2237337 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T63310 WP_000581793.1 NZ_CP015646:c2232396-2232187 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T63310 NZ_CP015646:c2232396-2232187 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT63310 WP_000138932.1 NZ_CP015646:c2232701-2232408 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT63310 NZ_CP015646:c2232701-2232408 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References