Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 967761..968238 Replicon chromosome
Accession NZ_CP015646
Organism Staphylococcus aureus strain 08-02300

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A7327_RS04660 Protein ID WP_000052076.1
Coordinates 967761..967949 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7327_RS04665 Protein ID WP_001059690.1
Coordinates 967978..968238 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7327_RS04630 963764..964273 + 510 WP_000824480.1 hypothetical protein -
A7327_RS04635 964614..965300 + 687 WP_001641381.1 thermonuclease family protein -
A7327_RS04640 965657..965857 + 201 WP_001059082.1 cold-shock protein -
A7327_RS04645 966352..966570 - 219 WP_000005889.1 hypothetical protein -
A7327_RS04650 966632..966916 - 285 WP_001004395.1 hypothetical protein -
A7327_RS04655 967004..967573 - 570 WP_001106654.1 hypothetical protein -
A7327_RS04660 967761..967949 - 189 WP_000052076.1 hypothetical protein Toxin
A7327_RS04665 967978..968238 - 261 WP_001059690.1 hypothetical protein Antitoxin
A7327_RS04670 968578..968781 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7327_RS04675 968778..969014 - 237 WP_000368687.1 hypothetical protein -
A7327_RS04680 969239..969820 + 582 WP_001140690.1 phosphoglycerate mutase family protein -
A7327_RS04685 969893..970510 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7327_RS04690 970664..971158 - 495 WP_064626748.1 GNAT family N-acetyltransferase -
A7327_RS04695 971557..971979 - 423 WP_000974447.1 organic hydroperoxide resistance protein -
A7327_RS04700 972127..972843 + 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T63304 WP_000052076.1 NZ_CP015646:c967949-967761 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T63304 NZ_CP015646:c967949-967761 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT63304 WP_001059690.1 NZ_CP015646:c968238-967978 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT63304 NZ_CP015646:c968238-967978 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References