Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1376616..1377093 Replicon chromosome
Accession NZ_CP015645
Organism Staphylococcus aureus strain 08-02119

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A7P66_RS07165 Protein ID WP_000052076.1
Coordinates 1376905..1377093 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7P66_RS07160 Protein ID WP_001059690.1
Coordinates 1376616..1376876 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P66_RS07125 1372009..1372725 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
A7P66_RS07130 1372873..1373295 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7P66_RS07135 1373694..1374188 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7P66_RS07140 1374343..1374960 + 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
A7P66_RS07145 1375033..1375614 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
A7P66_RS07150 1375839..1376075 + 237 WP_000368687.1 hypothetical protein -
A7P66_RS07155 1376072..1376275 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7P66_RS07160 1376616..1376876 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7P66_RS07165 1376905..1377093 + 189 WP_000052076.1 hypothetical protein Toxin
A7P66_RS07170 1377281..1377850 + 570 WP_001106652.1 hypothetical protein -
A7P66_RS07175 1377938..1378222 + 285 WP_001004394.1 hypothetical protein -
A7P66_RS07180 1378284..1378502 + 219 WP_042909089.1 hypothetical protein -
A7P66_RS07185 1378997..1379197 - 201 WP_001059082.1 cold-shock protein -
A7P66_RS07190 1379554..1380240 - 687 WP_001792695.1 thermonuclease family protein -
A7P66_RS07195 1380581..1381102 - 522 WP_042909090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(41-269)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-52)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T63295 WP_000052076.1 NZ_CP015645:1376905-1377093 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T63295 NZ_CP015645:1376905-1377093 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT63295 WP_001059690.1 NZ_CP015645:1376616-1376876 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT63295 NZ_CP015645:1376616-1376876 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References