Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 47571..48085 Replicon chromosome
Accession NZ_CP015645
Organism Staphylococcus aureus strain 08-02119

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag A7P66_RS00280 Protein ID WP_000581792.1
Coordinates 47876..48085 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag A7P66_RS00275 Protein ID WP_000138932.1
Coordinates 47571..47864 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7P66_RS00250 42919..43560 + 642 WP_000483153.1 thiamine phosphate synthase -
A7P66_RS00255 43646..44518 + 873 WP_000725802.1 membrane protein insertase YidC -
A7P66_RS00265 45246..45893 - 648 WP_001187634.1 HD domain-containing protein -
A7P66_RS00270 45921..47405 - 1485 WP_000571549.1 cardiolipin synthase -
A7P66_RS00275 47571..47864 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
A7P66_RS00280 47876..48085 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
A7P66_RS00285 48213..48350 + 138 WP_000828354.1 hypothetical protein -
A7P66_RS00290 48614..49816 - 1203 WP_001109939.1 rod shape-determining protein RodA -
A7P66_RS00295 50134..51204 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
A7P66_RS00300 51219..52577 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T63289 WP_000581792.1 NZ_CP015645:47876-48085 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T63289 NZ_CP015645:47876-48085 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT63289 WP_000138932.1 NZ_CP015645:47571-47864 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT63289 NZ_CP015645:47571-47864 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References