Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1657713..1658532 Replicon chromosome
Accession NZ_CP015642
Organism Staphylococcus simulans strain MR1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag A7X73_RS07940 Protein ID WP_106421061.1
Coordinates 1658059..1658532 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag A7X73_RS07935 Protein ID WP_105996454.1
Coordinates 1657713..1658045 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7X73_RS07880 1652946..1653392 - 447 WP_106421052.1 single-stranded DNA-binding protein -
A7X73_RS07885 1653392..1654063 - 672 WP_106421053.1 ERF family protein -
A7X73_RS07890 1654026..1654280 - 255 WP_106421054.1 DUF2483 family protein -
A7X73_RS07895 1654273..1654497 - 225 WP_106421055.1 hypothetical protein -
A7X73_RS07900 1654597..1654812 - 216 WP_106421056.1 hypothetical protein -
A7X73_RS07905 1654825..1655127 - 303 WP_002480770.1 DUF771 domain-containing protein -
A7X73_RS07910 1655242..1655565 + 324 WP_106421057.1 hypothetical protein -
A7X73_RS13785 1655554..1655712 - 159 WP_159079669.1 hypothetical protein -
A7X73_RS07915 1655759..1655986 - 228 WP_106421058.1 hypothetical protein -
A7X73_RS07920 1655987..1656760 - 774 WP_106421059.1 phage antirepressor KilAC domain-containing protein -
A7X73_RS07925 1656876..1657112 + 237 WP_105976070.1 hypothetical protein -
A7X73_RS13880 1657105..1657266 - 162 WP_182477690.1 hypothetical protein -
A7X73_RS07930 1657281..1657520 - 240 WP_106421060.1 helix-turn-helix domain-containing protein -
A7X73_RS07935 1657713..1658045 + 333 WP_105996454.1 helix-turn-helix domain-containing protein Antitoxin
A7X73_RS07940 1658059..1658532 + 474 WP_106421061.1 ImmA/IrrE family metallo-endopeptidase Toxin
A7X73_RS07945 1658519..1659160 + 642 WP_105976065.1 DUF4352 domain-containing protein -
A7X73_RS13790 1659339..1659479 + 141 WP_158257428.1 hypothetical protein -
A7X73_RS07950 1659574..1660089 + 516 WP_106421062.1 hypothetical protein -
A7X73_RS07955 1660091..1660399 + 309 WP_106421063.1 hypothetical protein -
A7X73_RS07960 1660464..1661492 + 1029 WP_106421064.1 site-specific integrase -
A7X73_RS07965 1661504..1661683 - 180 WP_180363558.1 RNA chaperone Hfq -
A7X73_RS07970 1661680..1662642 - 963 WP_106421065.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1622035..1661492 39457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 18576.85 Da        Isoelectric Point: 6.2286

>T63287 WP_106421061.1 NZ_CP015642:1658059-1658532 [Staphylococcus simulans]
MGVYEDLCIANDWVEIEETDRLPSFQPGFYRNGKIYIKSSLSEIRKAEVLYEELAHHKLTYGNILDESSFNNRKFENYAR
RHGYENSISLNKIIDAYKYGVSSLYEFAEYVQLSEEHVYTVLQHYKNKFGLSTCHNGYLIRFEPLQVFKYKKLNEGD

Download         Length: 474 bp

>T63287 NZ_CP015642:1658059-1658532 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTCTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAATACGAAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACATACGGAAATATACTTGATGAATCAAGTTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTGAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTATATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAACACGTATATACAGTGTTACAGCATTACAAAAATAAATTCGGTTTATCAACTT
GCCATAACGGCTATCTTATTCGATTTGAGCCATTGCAGGTTTTTAAATATAAAAAATTAAATGAAGGAGATTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12869.51 Da        Isoelectric Point: 4.7176

>AT63287 WP_105996454.1 NZ_CP015642:1657713-1658045 [Staphylococcus simulans]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFAKALHISTEYLLGFTESEQKEQEQDT
MAAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Download         Length: 333 bp

>AT63287 NZ_CP015642:1657713-1658045 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References