63275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 718139..718660 Replicon chromosome
Accession NZ_CP015626
Organism Staphylococcus pseudintermedius strain 063228

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag A6M57_RS03165 Protein ID WP_014613364.1
Coordinates 718439..718660 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag A6M57_RS03160 Protein ID WP_014613363.1
Coordinates 718139..718426 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6M57_RS03135 (A6M57_3330) 713400..714203 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
A6M57_RS03140 (A6M57_3335) 714193..714831 + 639 WP_014613359.1 thiamine phosphate synthase -
A6M57_RS03145 (A6M57_3340) 714920..715786 + 867 WP_014613360.1 membrane protein insertase YidC -
A6M57_RS03150 (A6M57_3345) 715840..716496 - 657 WP_014613361.1 HD domain-containing protein -
A6M57_RS03155 (A6M57_3350) 716517..718007 - 1491 WP_065520420.1 cardiolipin synthase -
A6M57_RS03160 (A6M57_3355) 718139..718426 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
A6M57_RS03165 (A6M57_3360) 718439..718660 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
A6M57_RS03170 (A6M57_3365) 718664..718870 + 207 WP_014613365.1 cation transporter -
A6M57_RS13265 (A6M57_3370) 718971..719444 + 474 WP_272899504.1 cation transporter -
A6M57_RS03175 (A6M57_3375) 719399..721369 + 1971 WP_272899505.1 copper-translocating P-type ATPase -
A6M57_RS13915 (A6M57_3380) 721455..721601 + 147 WP_014613367.1 Lmo0850 family protein -
A6M57_RS03185 (A6M57_3385) 722720..723448 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T63275 WP_014613364.1 NZ_CP015626:718439-718660 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T63275 NZ_CP015626:718439-718660 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT63275 WP_014613363.1 NZ_CP015626:718139-718426 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT63275 NZ_CP015626:718139-718426 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References