Detailed information of TA system TA063272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1497..2034
• Replicon: plasmid p6AsACE
• Accession: NZ_CP015621
• Organism: Acinetobacter schindleri strain ACE

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AsACE_RS15950
• Protein ID: WP_005265046.1
• Coordinates: 1744..2034 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: AsACE_RS15945
• Protein ID: WP_004871910.1
• Coordinates: 1497..1757 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AsACE_RS15935	68..604	+	537	WP_004986369.1	plasmid replication DNA-binding protein	-
AsACE_RS15940	890..1288	+	399	WP_076755278.1	hypothetical protein	-
AsACE_RS15945	1497..1757	+	261	WP_004871910.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AsACE_RS15950	1744..2034	+	291	WP_005265046.1	type II toxin-antitoxin system YafQ family toxin	Toxin
AsACE_RS15955	2511..3311	+	801	WP_076755281.1	YadA-like family protein	-
AsACE_RS15960	3377..4309	+	933	WP_076755283.1	IS5 family transposase	-
AsACE_RS15965	4367..4552	-	186	WP_076755285.1	YqaE/Pmp3 family membrane protein	-
AsACE_RS15970	4571..4852	-	282	WP_157759230.1	mobilization protein	-
AsACE_RS15975	5062..6498	+	1437	WP_076755289.1	MobA/MobL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..7943	7943
	-	flank	IS/Tn	-	-	3377..4309	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-69)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11213.96 Da
• Isoelectric Point: 8.8769

>T63272 WP_005265046.1 NZ_CP015621:1744-2034 [Acinetobacter schindleri]
MRTIKYTSAFKKDYKREKKGQHRNTVDAELQTVLELLQADETLPEKYRDHALVSNWVGHRDCHIKPDLVLIYKKTEEGEL
LILKLVRLGSHSELAI

Nucleotide

• Length: 291 bp

>T63272 NZ_CP015621:1744-2034 [Acinetobacter schindleri]
ATGCGGACGATTAAGTACACGTCTGCATTTAAGAAAGACTATAAACGTGAGAAAAAAGGTCAGCATCGAAATACAGTCGA
TGCTGAACTACAAACTGTTTTAGAGTTATTACAAGCCGATGAAACTTTGCCTGAAAAGTATCGTGACCATGCTTTGGTCA
GTAATTGGGTAGGTCATCGTGACTGCCATATCAAACCAGATCTTGTTTTAATCTATAAGAAAACAGAAGAAGGTGAACTA
CTCATTTTGAAGTTAGTTCGATTAGGTAGTCATAGTGAATTGGCGATTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9376.73 Da
• Isoelectric Point: 4.4217

>AT63272 WP_004871910.1 NZ_CP015621:1497-1757 [Acinetobacter schindleri]
MASNALVTTRINENIKHEATEVLATMGLTVSDAVRLLLTKVAKEKALPFDIWQPNAETIAAMEEDLSKAKSFTSVKDLMA
DLNADD

Nucleotide

• Length: 261 bp

>AT63272 NZ_CP015621:1497-1757 [Acinetobacter schindleri]
ATGGCTTCAAATGCACTAGTGACTACTCGCATCAATGAAAACATTAAGCATGAAGCAACGGAAGTTCTCGCAACAATGGG
CTTAACTGTCTCAGATGCAGTCCGTTTATTATTGACCAAAGTAGCTAAAGAAAAGGCTTTACCTTTTGATATTTGGCAAC
CCAATGCTGAAACCATTGCAGCGATGGAAGAAGATCTAAGCAAAGCAAAGAGCTTCACTTCTGTAAAAGACTTGATGGCT
GATCTAAATGCGGACGATTAA