Detailed information of TA system TA063269

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2577059..2577695
• Replicon: chromosome
• Accession: NZ_CP015615
• Organism: Acinetobacter schindleri strain ACE

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AsACE_RS12415
• Protein ID: WP_048881826.1
• Coordinates: 2577059..2577445 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: I4ZVX5
• Locus tag: AsACE_RS12420
• Protein ID: WP_008302635.1
• Coordinates: 2577438..2577695 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AsACE_RS12400	2572472..2574667	-	2196	WP_004809766.1	TRAP transporter large permease subunit	-
AsACE_RS12405	2574844..2575416	-	573	WP_034592075.1	rhombosortase	-
AsACE_RS12410	2575482..2576522	-	1041	WP_034592054.1	hypothetical protein	-
AsACE_RS12415	2577059..2577445	-	387	WP_048881826.1	hypothetical protein	Toxin
AsACE_RS12420	2577438..2577695	-	258	WP_008302635.1	succinate dehydrogenase assembly factor 2	Antitoxin
AsACE_RS12425	2577872..2579044	+	1173	WP_076754359.1	acyl-CoA dehydrogenase family protein	-
AsACE_RS12430	2579108..2580613	-	1506	WP_076754362.1	NAD(P)/FAD-dependent oxidoreductase	-
AsACE_RS12435	2580833..2581198	-	366	WP_004786886.1	50S ribosomal protein L17	-
AsACE_RS12440	2581217..2582224	-	1008	WP_004809777.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15522.54 Da
• Isoelectric Point: 9.6431

>T63269 WP_048881826.1 NZ_CP015615:c2577445-2577059 [Acinetobacter schindleri]
MDNRCYQLKRSLLALAFQFFIFIVLMFVMYQLLPLWLWGICLVAGLIIYHLFYRKRPQIAQFEYLDGREWTITHHDQRIQ
RAQISHVIDHQAYLVVYFQHAKVPPLLIWCDQLPTQQWKSLKVLTKMI

Nucleotide

• Length: 387 bp

>T63269 NZ_CP015615:c2577445-2577059 [Acinetobacter schindleri]
ATGGATAATCGTTGTTATCAGCTGAAACGCAGCCTGCTTGCACTTGCGTTTCAGTTTTTCATTTTTATTGTGTTGATGTT
TGTGATGTACCAGTTATTGCCCTTATGGCTATGGGGAATCTGTCTGGTTGCAGGACTGATCATCTATCATCTGTTTTATC
GCAAGCGTCCGCAGATCGCCCAGTTTGAATATCTGGATGGTCGGGAATGGACCATTACCCATCATGATCAGCGCATACAG
CGTGCCCAGATCAGTCATGTGATTGATCACCAAGCTTATCTGGTGGTGTATTTTCAGCATGCCAAAGTACCGCCATTGCT
GATCTGGTGTGACCAGTTACCAACACAACAATGGAAGTCATTGAAAGTCCTTACGAAAATGATCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10254.70 Da
• Isoelectric Point: 4.4898

>AT63269 WP_008302635.1 NZ_CP015615:c2577695-2577438 [Acinetobacter schindleri]
MTEDISLEERKVIYRARRGLKELDVYFDPYVKNCYLTADPFEKEMFAELVAQEDPDLLDWFMEVSEPPRPELREFINKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT63269 NZ_CP015615:c2577695-2577438 [Acinetobacter schindleri]
ATGACTGAAGACATCAGCCTGGAAGAGCGTAAAGTGATTTACCGCGCACGTCGTGGTCTTAAAGAGTTGGATGTGTATTT
TGATCCCTATGTCAAAAACTGCTATTTGACAGCAGACCCATTTGAAAAAGAAATGTTTGCTGAACTCGTAGCGCAAGAAG
ACCCGGACCTGCTGGACTGGTTTATGGAAGTATCCGAACCGCCACGTCCTGAATTACGTGAGTTTATTAACAAGCTTAAA
CACTACGTTCATGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A1P8PMS5