63267

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 4875594..4876116 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KX47
Locus tag Q5A_RS22435 Protein ID WP_006317109.1
Coordinates 4875594..4875875 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B1KWZ4
Locus tag Q5A_RS22440 Protein ID WP_006317110.1
Coordinates 4875865..4876116 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS22405 4870859..4871584 + 726 WP_006317106.1 LPS export ABC transporter ATP-binding protein -
Q5A_RS22410 4871635..4873068 + 1434 WP_006317107.1 RNA polymerase factor sigma-54 -
Q5A_RS22415 4873092..4873379 + 288 WP_004948547.1 ribosome hibernation promoting factor -
Q5A_RS22420 4873661..4874122 + 462 WP_004948550.1 PTS IIA-like nitrogen regulatory protein PtsN -
Q5A_RS22425 4874379..4875233 + 855 WP_004948553.1 RNase adapter RapZ -
Q5A_RS22430 4875230..4875502 + 273 WP_004948556.1 PTS phosphocarrier protein NPr -
Q5A_RS22435 4875594..4875875 - 282 WP_006317109.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q5A_RS22440 4875865..4876116 - 252 WP_006317110.1 hypothetical protein Antitoxin
Q5A_RS22445 4876222..4878138 - 1917 WP_006317111.1 BglG family transcription antiterminator -
Q5A_RS22450 4878191..4879405 - 1215 WP_006317112.1 lactonase family protein -
Q5A_RS22455 4879553..4880293 - 741 WP_006317113.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10853.63 Da        Isoelectric Point: 10.6974

>T63267 WP_006317109.1 NZ_CP015613:c4875875-4875594 [Serratia inhibens PRI-2C]
MSYNLKFEKRALKEWQKLGHPIREQLKKKLAERLENPHVPASRLSGRSNRYKIKLRSSGYRLVYEVNDTEVILLVIAVGK
RAGDEVYSIADKR

Download         Length: 282 bp

>T63267 NZ_CP015613:c4875875-4875594 [Serratia inhibens PRI-2C]
ATGAGCTATAATCTTAAATTCGAGAAACGTGCCCTGAAAGAATGGCAAAAATTGGGGCATCCTATCCGGGAACAATTGAA
AAAGAAGCTGGCGGAGCGGTTGGAGAATCCGCATGTGCCAGCTTCACGGCTCAGTGGCCGCAGTAATCGCTACAAGATTA
AATTGCGTTCATCCGGCTACCGGCTGGTTTATGAAGTTAATGATACTGAAGTCATTTTGTTAGTTATTGCAGTAGGAAAA
CGGGCAGGGGATGAAGTCTACTCAATTGCCGATAAACGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9120.21 Da        Isoelectric Point: 3.8705

>AT63267 WP_006317110.1 NZ_CP015613:c4876116-4875865 [Serratia inhibens PRI-2C]
MTYQILTTTAASITDLKKNPMGTVADGDGGAVAILNRNEPAFYCVPPALYAYYRELAEDAELNRIADERMEDAEFVSVSL
DEL

Download         Length: 252 bp

>AT63267 NZ_CP015613:c4876116-4875865 [Serratia inhibens PRI-2C]
ATGACCTATCAAATATTGACCACAACGGCTGCAAGTATCACGGATTTAAAAAAGAATCCAATGGGCACTGTCGCCGATGG
TGATGGTGGAGCAGTAGCCATATTAAACCGCAATGAGCCTGCTTTTTACTGCGTTCCTCCAGCGCTTTACGCTTACTATC
GAGAGCTTGCTGAAGATGCCGAACTGAATCGGATCGCAGATGAACGCATGGAGGATGCTGAGTTTGTGAGCGTGAGTCTC
GATGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KX47

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KWZ4

References