Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4395874..4396543 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name cptA Uniprot ID A0A1B1KVT8
Locus tag Q5A_RS20355 Protein ID WP_006319418.1
Coordinates 4395874..4396296 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1B1KVS1
Locus tag Q5A_RS20360 Protein ID WP_006319419.1
Coordinates 4396277..4396543 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS20335 4391759..4392277 + 519 WP_006319414.1 flavodoxin FldB -
Q5A_RS20340 4392315..4393679 - 1365 WP_006319415.1 cell envelope integrity protein CreD -
Q5A_RS20345 4393764..4395182 - 1419 WP_006319416.1 two-component system sensor histidine kinase CreC -
Q5A_RS20350 4395179..4395874 - 696 WP_006319417.1 two-component system response regulator CreB -
Q5A_RS20355 4395874..4396296 - 423 WP_006319418.1 protein YgfX Toxin
Q5A_RS20360 4396277..4396543 - 267 WP_006319419.1 FAD assembly factor SdhE Antitoxin
Q5A_RS20365 4396868..4397860 + 993 WP_006319420.1 tRNA-modifying protein YgfZ -
Q5A_RS20370 4397946..4398623 - 678 WP_043912556.1 hemolysin III family protein -
Q5A_RS20375 4398813..4399421 + 609 WP_006319430.1 HD domain-containing protein -
Q5A_RS20380 4399469..4400794 - 1326 WP_006319432.1 MHS family MFS transporter -
Q5A_RS20385 4400791..4401444 - 654 WP_006319433.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16554.45 Da        Isoelectric Point: 10.8466

>T63265 WP_006319418.1 NZ_CP015613:c4396296-4395874 [Serratia inhibens PRI-2C]
VAQWRCNVRISWRTQLFSLLTHGVLILLILIAPWPEGYGPLWLVLLTLVVFECIRSQKRIASRQGELRLLGNKRVSWHGQ
EWLLVKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLFQYPSADDDEEP

Download         Length: 423 bp

>T63265 NZ_CP015613:c4396296-4395874 [Serratia inhibens PRI-2C]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGTTATTCTCGCTGCTGACCCATGGCGTTTTGATCCT
GCTGATCCTGATTGCGCCCTGGCCGGAAGGCTACGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTGAATGTA
TCCGCAGCCAAAAGCGCATTGCGTCACGGCAGGGCGAATTGCGCCTGCTGGGGAATAAGCGTGTGAGCTGGCACGGACAG
GAATGGTTGCTGGTAAAGCAACCCTGGATGCCGCGTTACGGCATTCTGCTGACGCTGCAGCCGACGCAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGCTGTTTCAGTACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10474.91 Da        Isoelectric Point: 5.0843

>AT63265 WP_006319419.1 NZ_CP015613:c4396543-4396277 [Serratia inhibens PRI-2C]
MDINNRARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT63265 NZ_CP015613:c4396543-4396277 [Serratia inhibens PRI-2C]
ATGGATATTAATAATAGAGCACGTATTCACTGGGCCTGCCGCCGTGGTATGCGCGAACTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCCCTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KVT8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KVS1

References