Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3972762..3973229 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KUP0
Locus tag Q5A_RS18435 Protein ID WP_006316908.1
Coordinates 3972762..3973031 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B1KUV0
Locus tag Q5A_RS18440 Protein ID WP_006316909.1
Coordinates 3973035..3973229 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS18405 3967826..3968341 + 516 WP_006316896.1 hypothetical protein -
Q5A_RS18410 3968380..3968628 + 249 WP_006316897.1 GlsB/YeaQ/YmgE family stress response membrane protein -
Q5A_RS18415 3968678..3969958 - 1281 WP_006316898.1 uracil permease -
Q5A_RS18420 3970151..3970777 - 627 WP_006316899.1 uracil phosphoribosyltransferase -
Q5A_RS18425 3971033..3972070 + 1038 WP_006316901.1 phosphoribosylformylglycinamidine cyclo-ligase -
Q5A_RS18430 3972070..3972708 + 639 WP_004951897.1 phosphoribosylglycinamide formyltransferase -
Q5A_RS18435 3972762..3973031 - 270 WP_006316908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q5A_RS18440 3973035..3973229 - 195 WP_006316909.1 hypothetical protein Antitoxin
Q5A_RS18445 3973376..3973927 + 552 WP_006316910.1 spermidine N1-acetyltransferase -
Q5A_RS18450 3973987..3974799 - 813 WP_006316912.1 phosphate ABC transporter ATP-binding protein -
Q5A_RS18455 3974828..3976480 - 1653 WP_006316914.1 phosphate ABC transporter permease PstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10611.19 Da        Isoelectric Point: 6.0726

>T63261 WP_006316908.1 NZ_CP015613:c3973031-3972762 [Serratia inhibens PRI-2C]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLG
VIHAKREYP

Download         Length: 270 bp

>T63261 NZ_CP015613:c3973031-3972762 [Serratia inhibens PRI-2C]
ATGCGGATAGAATGGAGTCGTGAAGCTCAGGAAGAGCTATGGAACATTATTGATTATATTGATGATAGAAACCCGCAGGC
GGCGCTCATTTTACAGCGCGAGATCGAAACGGCGGTGCATTCGCTGTCGCTGAATCCCTTTATGTACCGATTGGGTAGAG
TAGATAACACTCGTGAGATTGTCGTCCATCCCAACTACCTGATTGTTTATAGAATCATCGGACATATAGAAGTTCTTGGC
GTGATTCACGCTAAACGAGAATATCCCTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7429.62 Da        Isoelectric Point: 10.2045

>AT63261 WP_006316909.1 NZ_CP015613:c3973229-3973035 [Serratia inhibens PRI-2C]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRVPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT63261 NZ_CP015613:c3973229-3973035 [Serratia inhibens PRI-2C]
ATGGTGATCAAAACCTCCCTCTCCACCCAGCCCACAGCTGAGGTAGCCGAACAAGGCGAAAGTTACGATCGTTGGTTCCG
GGCCAAGATTGAAGCAGCCATTAACAGCGAAAAGCCAAGAGTTCCGCACGAGCAGGTCATGAACGAGATGCAAATTCGTT
TAGCTGCAAAGAAAAAGATACGCAAAATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUV0

References