Detailed information of TA system TA063260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3267074..3267705
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Q5A_RS15210
• Protein ID: WP_006321481.1
• Coordinates: 3267074..3267472 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1KSY2
• Locus tag: Q5A_RS15215
• Protein ID: WP_006321482.1
• Coordinates: 3267472..3267705 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS15185	3262643..3263029	+	387	WP_006321465.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Q5A_RS15190	3263010..3263312	+	303	WP_006321467.1	helix-turn-helix domain-containing protein	-
Q5A_RS15195	3263317..3263721	-	405	WP_006321469.1	flagellar protein FlhE	-
Q5A_RS15200	3263721..3265799	-	2079	WP_006321478.1	flagellar biosynthesis protein FlhA	-
Q5A_RS15205	3265792..3266943	-	1152	WP_006321480.1	flagellar type III secretion system protein FlhB	-
Q5A_RS15210	3267074..3267472	-	399	WP_006321481.1	type II toxin-antitoxin system VapC family toxin	Toxin
Q5A_RS15215	3267472..3267705	-	234	WP_006321482.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
Q5A_RS15220	3267843..3268487	-	645	WP_006321483.1	protein phosphatase CheZ	-
Q5A_RS15225	3268498..3268887	-	390	WP_006321484.1	chemotaxis response regulator CheY	-
Q5A_RS15230	3269108..3270157	-	1050	WP_006321485.1	chemotaxis response regulator protein-glutamate methylesterase	-
Q5A_RS15235	3270157..3271029	-	873	WP_006321486.1	protein-glutamate O-methyltransferase CheR	-
Q5A_RS15240	3271058..3272683	-	1626	WP_006321487.1	Tar ligand binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14935.10 Da
• Isoelectric Point: 6.7607

>T63260 WP_006321481.1 NZ_CP015613:c3267472-3267074 [Serratia inhibens PRI-2C]
MFSHMLDTNMVIYVIKRRPFEVLEMFNQHAGNMVISSITYAELIHGVEKSARPAANSRVIDDFVSRLDILDYGPKAAAHY
GNIRSALERQGTPIGVNDLHIAGHARSEGLILVSNNMREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T63260 NZ_CP015613:c3267472-3267074 [Serratia inhibens PRI-2C]
ATGTTTAGCCATATGCTGGATACCAATATGGTTATCTATGTCATCAAGCGCCGGCCGTTTGAAGTGCTGGAGATGTTCAA
TCAGCACGCGGGCAACATGGTAATCTCATCGATCACTTACGCGGAGTTGATCCACGGGGTAGAAAAAAGTGCCCGGCCGG
CCGCGAACTCGCGGGTGATTGACGACTTCGTTTCACGATTGGATATCCTCGATTACGGCCCCAAGGCCGCTGCGCATTAC
GGTAATATCCGCAGTGCACTTGAACGGCAGGGCACGCCTATTGGTGTCAACGACCTGCATATTGCCGGACACGCGCGCAG
CGAAGGTTTGATTCTTGTTAGCAATAACATGCGTGAATTTGAACGTGTCGAAGGCCTGCGCCTCGAGAATTGGTTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8831.77 Da
• Isoelectric Point: 4.5822

>AT63260 WP_006321482.1 NZ_CP015613:c3267705-3267472 [Serratia inhibens PRI-2C]
MTLGSVFTNNRTQAVRLPAEVRFPDSVSRVTVRVVGKERILSPVENTWDSFFCAENDASEDFLTERAEQHQPERESF

Nucleotide

• Length: 234 bp

>AT63260 NZ_CP015613:c3267705-3267472 [Serratia inhibens PRI-2C]
ATGACTTTAGGATCAGTGTTTACCAATAATCGCACTCAGGCAGTGCGTTTACCGGCAGAGGTGCGTTTCCCTGACTCGGT
ATCCAGGGTCACCGTGCGTGTGGTTGGCAAAGAGCGCATTCTTTCTCCGGTGGAAAATACCTGGGACAGCTTCTTCTGTG
CGGAAAACGACGCTAGCGAGGATTTTCTCACCGAAAGGGCCGAACAGCATCAGCCTGAGCGGGAAAGTTTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1KSY2