Detailed information of TA system TA063259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3226147..3226772
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Q5A_RS25690
• Protein ID: WP_006321377.1
• Coordinates: 3226147..3226329 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1B1KSS5
• Locus tag: Q5A_RS14965
• Protein ID: WP_006321379.1
• Coordinates: 3226359..3226772 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS14960	3222009..3225980	+	3972	WP_006321375.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
Q5A_RS25690	3226147..3226329	+	183	WP_006321377.1	type II toxin-antitoxin system HicA family toxin	Toxin
Q5A_RS14965	3226359..3226772	+	414	WP_006321379.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Q5A_RS14970	3226805..3227557	-	753	WP_006321380.1	L-cystine ABC transporter ATP-binding protein YecC	-
Q5A_RS14975	3227561..3228223	-	663	WP_006321381.1	cystine ABC transporter permease	-
Q5A_RS14980	3228223..3229023	-	801	WP_006321382.1	cystine ABC transporter substrate-binding protein	-
Q5A_RS14985	3229138..3230130	-	993	WP_006321383.1	D-cysteine desulfhydrase	-
Q5A_RS14990	3230258..3230767	-	510	WP_006321385.1	flagella biosynthesis regulatory protein FliZ	-
Q5A_RS14995	3230825..3231547	-	723	WP_006321387.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7004.29 Da
• Isoelectric Point: 11.5336

>T63259 WP_006321377.1 NZ_CP015613:3226147-3226329 [Serratia inhibens PRI-2C]
VKSAELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMRDAGLC

Nucleotide

• Length: 183 bp

>T63259 NZ_CP015613:3226147-3226329 [Serratia inhibens PRI-2C]
GTGAAAAGTGCAGAACTGATCAGACTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGTCACCATCAGTT
TAAACACCCGAGATCACGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAGAGATGCCGGGTTGTGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14944.70 Da
• Isoelectric Point: 5.0777

>AT63259 WP_006321379.1 NZ_CP015613:3226359-3226772 [Serratia inhibens PRI-2C]
MFYPAYVHSDHDGSASGFFPDVPGCYFAGDTLDLAFADAKSALDAHFELLSEDNQAIPRPQAVSLHLAQASDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSMVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT63259 NZ_CP015613:3226359-3226772 [Serratia inhibens PRI-2C]
ATGTTCTACCCTGCTTATGTACATTCAGACCACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGCTATTT
TGCCGGCGATACCCTCGATCTCGCCTTTGCAGACGCCAAAAGCGCACTGGATGCGCATTTCGAACTGCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTGCATCTGGCACAGGCAAGCGACACCCTGAACGGTGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGCCGGGCGGAACGTATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCAATGGTGCAACAGCATCCCGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAACGAATTAT
TGAAAGCCGGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1B1KSS5