63250

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1740414..1740939 Replicon chromosome
Accession NZ_CP015613
Organism Serratia inhibens PRI-2C

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KNV3
Locus tag Q5A_RS08145 Protein ID WP_006320891.1
Coordinates 1740414..1740698 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B1KNT6
Locus tag Q5A_RS08150 Protein ID WP_006320890.1
Coordinates 1740688..1740939 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q5A_RS08120 1735672..1736805 + 1134 WP_006320896.1 putrescine ABC transporter ATP-binding subunit PotG -
Q5A_RS08125 1736836..1737795 + 960 WP_119804113.1 putrescine ABC transporter permease PotH -
Q5A_RS08130 1737792..1738637 + 846 WP_006320894.1 putrescine ABC transporter permease PotI -
Q5A_RS08135 1738740..1739219 + 480 WP_043912936.1 DUF2593 family protein -
Q5A_RS08140 1739290..1740417 + 1128 WP_006320892.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
Q5A_RS08145 1740414..1740698 - 285 WP_006320891.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q5A_RS08150 1740688..1740939 - 252 WP_006320890.1 prevent-host-death protein Antitoxin
Q5A_RS08155 1741051..1741785 - 735 WP_006320889.1 arginine ABC transporter substrate-binding protein -
Q5A_RS08160 1741988..1742656 - 669 WP_006320888.1 arginine ABC transporter permease ArtM -
Q5A_RS08165 1742656..1743372 - 717 WP_006320887.1 arginine ABC transporter permease ArtQ -
Q5A_RS08170 1743382..1744113 - 732 WP_006320886.1 arginine ABC transporter substrate-binding protein -
Q5A_RS08175 1744147..1744875 - 729 WP_006320885.1 arginine ABC transporter ATP-binding protein ArtP -
Q5A_RS08180 1745132..1745680 - 549 WP_006320884.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.79 Da        Isoelectric Point: 9.6713

>T63250 WP_006320891.1 NZ_CP015613:c1740698-1740414 [Serratia inhibens PRI-2C]
MTYSLEFEEHALKEFKKLAPVLRDQFKKKLATVLENPCIPANRLSGLPDCYKIKLKASGYRLVYRVIDEEIVVLVLSIGK
RERSEAYTAAKKCL

Download         Length: 285 bp

>T63250 NZ_CP015613:c1740698-1740414 [Serratia inhibens PRI-2C]
ATGACTTATAGCCTTGAATTCGAAGAACATGCACTAAAGGAATTTAAGAAACTGGCCCCGGTACTTCGGGATCAATTCAA
GAAAAAACTGGCAACAGTATTAGAAAATCCATGTATTCCCGCCAATAGACTCTCTGGCCTACCGGATTGCTATAAAATAA
AACTTAAGGCTTCCGGTTACCGTCTGGTCTATCGCGTCATCGACGAGGAGATTGTGGTGCTGGTACTTTCGATAGGTAAG
CGTGAGCGCTCAGAGGCCTATACGGCTGCCAAAAAATGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9095.44 Da        Isoelectric Point: 6.2821

>AT63250 WP_006320890.1 NZ_CP015613:c1740939-1740688 [Serratia inhibens PRI-2C]
MIVQPILANSAVSISDFKKSPNTALKEANGQPVAVLTNGKISGYYVSPETWEAISEYLEDIELAKIARSRMSGKRIKVNL
DDL

Download         Length: 252 bp

>AT63250 NZ_CP015613:c1740939-1740688 [Serratia inhibens PRI-2C]
ATGATCGTTCAGCCTATCCTCGCAAACTCAGCCGTCAGCATCAGTGATTTTAAAAAATCGCCTAACACTGCGCTCAAAGA
AGCCAACGGACAACCTGTGGCAGTACTTACCAATGGAAAGATCTCCGGCTATTACGTCTCTCCGGAAACGTGGGAAGCAA
TCTCTGAATACCTGGAAGATATCGAACTCGCAAAAATAGCCCGCTCACGGATGAGTGGCAAACGTATTAAGGTCAATCTG
GATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KNV3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KNT6

References