Detailed information of TA system TA063249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1615871..1616424
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A1B1KNI3
• Locus tag: Q5A_RS07640
• Protein ID: WP_006322177.1
• Coordinates: 1616116..1616424 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: Q5A_RS07635
• Protein ID: WP_006322175.1
• Coordinates: 1615871..1616113 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS07620	1612359..1613897	+	1539	WP_006322169.1	glutathione ABC transporter substrate-binding protein GsiB	-
Q5A_RS07625	1613950..1614870	+	921	WP_006322171.1	glutathione ABC transporter permease GsiC	-
Q5A_RS07630	1614880..1615788	+	909	WP_006322173.1	glutathione ABC transporter permease GsiD	-
Q5A_RS07635	1615871..1616113	+	243	WP_006322175.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
Q5A_RS07640	1616116..1616424	+	309	WP_006322177.1	CcdB family protein	Toxin
Q5A_RS07645	1616461..1617303	-	843	WP_006322178.1	S-formylglutathione hydrolase	-
Q5A_RS07650	1617318..1618445	-	1128	WP_006322179.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
Q5A_RS07655	1618474..1619391	-	918	WP_006322180.1	LysR family transcriptional regulator	-
Q5A_RS07660	1619499..1620656	+	1158	WP_006322181.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (10-80)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11506.38 Da
• Isoelectric Point: 5.0758

>T63249 WP_006322177.1 NZ_CP015613:1616116-1616424 [Serratia inhibens PRI-2C]
MQFTVYDNIYPASAYPYLLDVQSDLIDVLSTRLMIPLYSLEKVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGEA
VGNANEHRSKIKAAIDFLIDGF

Nucleotide

• Length: 309 bp

>T63249 NZ_CP015613:1616116-1616424 [Serratia inhibens PRI-2C]
ATGCAGTTTACCGTATATGACAATATATATCCGGCATCGGCTTATCCATATCTGCTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCTACTCGGTTAATGATCCCACTTTATTCTTTGGAGAAAGTCAGGGTCAAAATTTCTGCGCGTTTATGCCCGG
AAATTGAGGTGAACGGCGAAAAGTTTTTAGTTATGACGCATGAGATGGCTGCCGTGCGTATTTCGCAGATAGGGGAGGCC
GTTGGTAATGCCAATGAGCATAGGAGTAAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9183.30 Da
• Isoelectric Point: 4.7719

>AT63249 WP_006322175.1 NZ_CP015613:1615871-1616113 [Serratia inhibens PRI-2C]
MDMANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRAF

Nucleotide

• Length: 243 bp

>AT63249 NZ_CP015613:1615871-1616113 [Serratia inhibens PRI-2C]
ATGGATATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGTGCAAAATC
CCTGGGTGTCAATGTGTCATCCGTATTAACGGATGCATTGAGCGTACGTGTTAGAGACATTGAGATTCAACAGTGGCGTG
AGCAAAATCGCGCAGCGTTAGAAGAGCTTAATCGCATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGGCATTT
TGA

Structures

Toxin

• AlphaFold DB: A0A1B1KNI3