Detailed information of TA system TA063247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 891930..892466
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Q5A_RS26970
• Protein ID: WP_202817100.1
• Coordinates: 891930..892055 (-)
• Length: 42 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B1KLJ4
• Locus tag: Q5A_RS04135
• Protein ID: WP_006322397.1
• Coordinates: 892188..892466 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS04115	886977..887927	-	951	WP_043913281.1	acetyltransferase	-
Q5A_RS04120	887924..889669	-	1746	WP_006322400.1	aerobactin synthase IucA	-
Q5A_RS04125	889807..891030	+	1224	WP_006322399.1	MFS transporter	-
Q5A_RS04130	891036..891920	+	885	WP_006322398.1	siderophore-interacting protein	-
Q5A_RS26970	891930..892055	-	126	WP_202817100.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q5A_RS04135	892188..892466	-	279	WP_006322397.1	CopG family ribbon-helix-helix protein	Antitoxin
Q5A_RS04140	892552..892938	-	387	WP_006322396.1	oxalurate catabolism protein HpxZ	-
Q5A_RS04145	892942..894342	-	1401	WP_006322395.1	AtzE family amidohydrolase	-
Q5A_RS04150	894339..894530	-	192	WP_006322394.1	oxalurate catabolism protein HpxX	-
Q5A_RS04155	894556..896142	-	1587	WP_006322393.1	gamma-glutamyltransferase	-
Q5A_RS04160	896287..897126	+	840	WP_006322392.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4671.31 Da
• Isoelectric Point: 5.5944

>T63247 WP_202817100.1 NZ_CP015613:c892055-891930 [Serratia inhibens PRI-2C]
MAPEFREWPVDFGNSGYLVLYRLNGVTAVILAIRHQSETGY

Nucleotide

• Length: 126 bp

>T63247 NZ_CP015613:c892055-891930 [Serratia inhibens PRI-2C]
ATGGCACCTGAATTCAGGGAGTGGCCTGTCGATTTCGGCAATAGCGGTTATCTTGTTCTGTATCGGCTTAACGGTGTAAC
CGCCGTTATTTTGGCTATTCGCCACCAAAGTGAAACTGGATATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10604.65 Da
• Isoelectric Point: 4.7465

>AT63247 WP_006322397.1 NZ_CP015613:c892466-892188 [Serratia inhibens PRI-2C]
MATATSIKIDDELKQRVQHIAATHQRSAHWIMREAIREYVECEEKREAVRNDALQAWETYQANGKHLTQDEADGWLSDLE
KGDDTEIPGCHN

Nucleotide

• Length: 279 bp

>AT63247 NZ_CP015613:c892466-892188 [Serratia inhibens PRI-2C]
ATGGCTACTGCTACGTCGATAAAAATTGATGATGAGCTTAAACAACGGGTGCAACACATTGCCGCTACCCACCAGCGCAG
CGCACACTGGATTATGCGTGAAGCTATCCGTGAATATGTCGAGTGTGAAGAAAAACGCGAGGCTGTTCGCAACGATGCAT
TGCAGGCATGGGAAACCTATCAGGCCAATGGTAAACATTTGACTCAGGACGAGGCCGACGGCTGGCTCTCCGATCTGGAA
AAAGGTGACGATACGGAGATACCCGGGTGCCACAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B1KLJ4