Detailed information of TA system TA063246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 515691..516218
• Replicon: chromosome
• Accession: NZ_CP015613
• Organism: Serratia inhibens PRI-2C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B1KKK6
• Locus tag: Q5A_RS02390
• Protein ID: WP_065505837.1
• Coordinates: 515943..516218 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Q5A_RS02385
• Protein ID: WP_065506804.1
• Coordinates: 515691..515939 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Q5A_RS02365	511229..512299	+	1071	WP_020825022.1	LPS export ABC transporter permease LptG	-
Q5A_RS02370	512507..513223	+	717	WP_065505835.1	LuxR family transcriptional regulator	-
Q5A_RS02375	513224..513868	-	645	WP_065505836.1	acyl-homoserine-lactone synthase	-
Q5A_RS26265	514695..514967	-	273	WP_148661005.1	hypothetical protein	-
Q5A_RS25240	515166..515471	+	306	Protein_453	integrase	-
Q5A_RS02385	515691..515939	+	249	WP_065506804.1	ribbon-helix-helix domain-containing protein	Antitoxin
Q5A_RS02390	515943..516218	+	276	WP_065505837.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Q5A_RS02395	516437..517072	+	636	WP_065505838.1	carbonic anhydrase	-
Q5A_RS02400	517280..517576	+	297	WP_065505839.1	helix-turn-helix transcriptional regulator	-
Q5A_RS02405	517952..518485	+	534	WP_065506805.1	hypothetical protein	-
Q5A_RS02410	518935..520428	+	1494	WP_148661006.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	512507..537217	24710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10940.31 Da
• Isoelectric Point: 5.1450

>T63246 WP_065505837.1 NZ_CP015613:515943-516218 [Serratia inhibens PRI-2C]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLIVGSAGLSAHPAIGIQQTRYEPREVRKVLFDDYEVHYELRDTAIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T63246 NZ_CP015613:515943-516218 [Serratia inhibens PRI-2C]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACCTGGAACGTATCTACCGTTTTGCCCTGCAGTACAGCCGCCAGCA
TGCCGATGACGTTTTAGACCGTTTGATAGTCGGCAGCGCCGGCCTTTCGGCACACCCGGCAATCGGCATACAGCAGACTC
GATATGAACCTCGGGAAGTTCGAAAAGTGTTATTCGATGACTACGAGGTTCACTACGAACTCCGCGACACTGCCATCTAC
ATCGTGGATCTCTGGCATACAAAAGAAGAACGATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9046.39 Da
• Isoelectric Point: 7.2042

>AT63246 WP_065506804.1 NZ_CP015613:515691-515939 [Serratia inhibens PRI-2C]
MGSLTKQTISAQIPVELAVAVENLAIELDRSKSWIIKEALTRMLAESERRHQSIQAGLADVDAGRVVSHSDMVDFANRLK
KT

Nucleotide

• Length: 249 bp

>AT63246 NZ_CP015613:515691-515939 [Serratia inhibens PRI-2C]
ATGGGTTCGCTTACTAAACAAACCATCAGTGCACAGATACCCGTTGAGTTGGCTGTTGCTGTCGAAAATCTGGCTATTGA
GTTGGATCGTTCTAAAAGCTGGATTATCAAGGAAGCCTTGACCCGTATGCTGGCCGAGAGTGAACGGCGTCACCAGAGCA
TCCAGGCCGGTCTTGCCGATGTGGATGCCGGTCGCGTAGTGAGTCATTCGGACATGGTGGATTTTGCCAATCGTTTAAAG
AAAACCTGA

Structures

Toxin

• AlphaFold DB: A0A1B1KKK6