Detailed information of TA system TA063242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 267554..268202
• Replicon: chromosome
• Accession: NZ_CP015612
• Organism: Stenotrophomonas maltophilia strain OUC_Est10

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: A7326_RS01175
• Protein ID: WP_088023456.1
• Coordinates: 267554..267841 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: M5D621
• Locus tag: A7326_RS01180
• Protein ID: WP_004136950.1
• Coordinates: 267900..268202 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7326_RS01145	262801..263769	+	969	WP_088023441.1	bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA	-
A7326_RS01150	263766..264497	+	732	WP_049454338.1	type III pantothenate kinase	-
A7326_RS01155	264507..265370	+	864	WP_088023443.1	SPOR domain-containing protein	-
A7326_RS01165	265571..266695	-	1125	WP_088023450.1	hypothetical protein	-
A7326_RS01170	266723..267322	-	600	WP_132808851.1	hypothetical protein	-
A7326_RS01175	267554..267841	+	288	WP_088023456.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A7326_RS01180	267900..268202	+	303	WP_004136950.1	putative addiction module antidote protein	Antitoxin
A7326_RS01185	268378..268779	-	402	WP_088023458.1	hypothetical protein	-
A7326_RS01190	269373..270143	+	771	WP_088023460.1	DUF3011 domain-containing protein	-
A7326_RS01195	270202..271146	+	945	WP_088023463.1	ankyrin repeat domain-containing protein	-
A7326_RS01200	271165..271512	-	348	WP_088023466.1	hypothetical protein	-
A7326_RS01205	271645..272565	+	921	WP_088023469.1	arginase	-
A7326_RS01210	272728..272865	+	138	WP_019661832.1	entericidin A/B family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10715.34 Da
• Isoelectric Point: 10.9963

>T63242 WP_088023456.1 NZ_CP015612:267554-267841 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLANGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAKEIARAL

Nucleotide

• Length: 288 bp

>T63242 NZ_CP015612:267554-267841 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCCGGTGATCACCGCTATCTGGCGAATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCGGGTTACCGCGTTTACTACACCCAGCGCGGCAGGCAGTTGGTGATTCTCCTGGTTGGAGGCGACAAGGGTTCG
CAGCAGCGCGATATCGAGAAGGCCAAGGAGATTGCGCGTGCCCTGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10706.32 Da
• Isoelectric Point: 8.0343

>AT63242 WP_004136950.1 NZ_CP015612:267900-268202 [Stenotrophomonas maltophilia]
MAIKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Nucleotide

• Length: 303 bp

>AT63242 NZ_CP015612:267900-268202 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAAGAAAGTCGAACTCAAAGCATTTGATGTGGCCGAGCACCTTCGGACACCGGAGGAGATGGCGGCCTA
TCTCGATGCCTGCATCGAGGAAAGCGATGGCGATTCCGCGTTCATTGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GCATGAGCAAGGTTGCGCGTGCGGCGGGCTTGTCGCGCGAGAGTCTGTATCGCGCACTGTCCGGCGAGCGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCCTGGGTGTGCGATTGCATGCCAGCGCAGCATAA

Structures

Antitoxin

• AlphaFold DB: M5D621