Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 9087..9720 Replicon plasmid pP27494_2
Accession NZ_CP015602
Organism Pseudomonas antarctica strain PAMC 27494

Toxin (Protein)


Gene name vapC Uniprot ID A0A172ZAE6
Locus tag A7J50_RS30090 Protein ID WP_064455169.1
Coordinates 9319..9720 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A7J50_RS31255 Protein ID WP_082896019.1
Coordinates 9087..9326 (+) Length 80 a.a.

Genomic Context

A7J50_RS30080A7J50_RS30085A7J50_RS31255A7J50_RS30090A7J50_RS30095A7J50_RS30100A7J50_RS30105A7J50_RS30115A7J50_RS30120A7J50_RS31260A7J50_RS30125A7J50_RS30060A7J50_RS30065A7J50_RS30070A7J50_RS30110
Location: 7147..7959 (813 bp)
Type: Others
Protein ID: WP_156526341.1
Location: 8723..9019 (297 bp)
Type: Others
Protein ID: WP_064455144.1
Location: 9087..9326 (240 bp)
Type: Antitoxin
Protein ID: WP_082896019.1
Location: 9319..9720 (402 bp)
Type: Toxin
Protein ID: WP_064455169.1
Location: 9736..10182 (447 bp)
Type: Others
Protein ID: WP_064455145.1
Location: 10981..11523 (543 bp)
Type: Others
Protein ID: WP_064455146.1
Location: 11526..12671 (1146 bp)
Type: Others
Protein ID: WP_064455147.1
Location: 13275..13505 (231 bp)
Type: Others
Protein ID: WP_064455149.1
Location: 13505..13903 (399 bp)
Type: Others
Protein ID: WP_064455150.1
Location: 14155..14334 (180 bp)
Type: Others
Protein ID: WP_082896020.1
Location: 14331..14543 (213 bp)
Type: Others
Protein ID: WP_064455151.1
Location: 4956..5234 (279 bp)
Type: Others
Protein ID: WP_064455139.1
Location: 5279..5737 (459 bp)
Type: Others
Protein ID: WP_064455140.1
Location: 5989..6210 (222 bp)
Type: Others
Protein ID: WP_064455141.1
Location: 12681..13016 (336 bp)
Type: Others
Protein ID: WP_064455148.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A7J50_RS300604956..5234-279WP_064455139.1hypothetical protein-
A7J50_RS300655279..5737-459WP_064455140.1hypothetical protein-
A7J50_RS300705989..6210-222WP_064455141.1helix-turn-helix domain-containing protein-
A7J50_RS300807147..7959+813WP_156526341.1plasmid replication protein repA-
A7J50_RS300858723..9019+297WP_064455144.1hypothetical protein-
A7J50_RS312559087..9326+240WP_082896019.1antitoxinAntitoxin
A7J50_RS300909319..9720+402WP_064455169.1tRNA(fMet)-specific endonuclease VapCToxin
A7J50_RS300959736..10182+447WP_064455145.1hypothetical protein-
A7J50_RS3010010981..11523+543WP_064455146.1hypothetical protein-
A7J50_RS3010511526..12671+1146WP_064455147.1hypothetical protein-
A7J50_RS3011012681..13016-336WP_064455148.1FxLYD domain-containing protein-
A7J50_RS3011513275..13505+231WP_064455149.1antitoxin-
A7J50_RS3012013505..13903+399WP_064455150.1tRNA(fMet)-specific endonuclease VapC-
A7J50_RS3126014155..14334+180WP_082896020.1CrpP family protein-
A7J50_RS3012514331..14543+213WP_064455151.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3011630116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14901.22 Da        Isoelectric Point: 7.3571

>T63237 WP_064455169.1 NZ_CP015602:9319-9720 [Pseudomonas antarctica]
MIKYMLDTNIVIYVIKRRPVEVLEKFNANAGRMVISSITLAELMHGAEKSAFIEKNTRAVEDFISRLDVLNYDEKAACHY
GSIRADLEKKGITIGVNDLHIAGHARSSGLVVVTNNVNEFNRVNGLIVENWIV

Download         Length: 402 bp

>T63237 NZ_CP015602:9319-9720 [Pseudomonas antarctica]
ATGATTAAATACATGCTTGATACGAATATTGTAATTTATGTGATCAAGCGTCGGCCTGTCGAGGTGTTGGAAAAATTCAA
TGCCAATGCGGGCCGGATGGTTATTTCGTCAATCACATTAGCCGAACTAATGCACGGTGCAGAAAAAAGCGCTTTCATTG
AAAAGAACACGCGAGCTGTGGAGGACTTCATTTCAAGACTCGACGTTTTGAACTACGATGAAAAGGCAGCCTGCCACTAC
GGCTCGATACGTGCGGACCTGGAGAAAAAAGGTATCACGATAGGGGTTAATGATTTGCATATAGCTGGACATGCCCGAAG
TTCAGGTTTAGTCGTTGTCACGAACAACGTAAATGAATTCAACCGCGTGAACGGTTTAATTGTCGAAAACTGGATTGTTT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9001.95 Da        Isoelectric Point: 4.3707

>AT63237 WP_082896019.1 NZ_CP015602:9087-9326 [Pseudomonas antarctica]
MSQGTIFTNNRTQNIRIPADMRFPADVKTVIVRAVGHERIIAPIENTWDSFFLGGESVSNDFMNERADQAQSEREPFDD

Download         Length: 240 bp

>AT63237 NZ_CP015602:9087-9326 [Pseudomonas antarctica]
ATGTCTCAAGGAACTATATTCACCAATAACCGAACACAAAACATCCGTATCCCTGCGGATATGCGGTTTCCTGCGGATGT
TAAAACAGTCATTGTGCGGGCTGTCGGGCACGAACGCATCATTGCCCCCATTGAAAACACTTGGGATAGTTTTTTCCTTG
GCGGTGAGTCAGTTTCAAACGACTTCATGAATGAACGAGCTGACCAGGCACAAAGCGAAAGAGAACCGTTCGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A172ZAE6

Antitoxin

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Source
ID
Structure
No matching records found

References