Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3649900..3650513 Replicon chromosome
Accession NZ_CP015600
Organism Pseudomonas antarctica strain PAMC 27494

Toxin (Protein)


Gene name hicA Uniprot ID A0A172Z267
Locus tag A7J50_RS16305 Protein ID WP_053256594.1
Coordinates 3649900..3650151 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A172Z377
Locus tag A7J50_RS16310 Protein ID WP_064452746.1
Coordinates 3650148..3650513 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7J50_RS16305 3649900..3650151 + 252 WP_053256594.1 type II toxin-antitoxin system HicA family toxin Toxin
A7J50_RS16310 3650148..3650513 + 366 WP_064452746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7J50_RS16315 3650496..3651686 - 1191 WP_064452747.1 MFS transporter -
A7J50_RS16320 3651829..3652422 + 594 WP_064452748.1 TetR/AcrR family transcriptional regulator -
A7J50_RS16325 3652406..3653761 - 1356 WP_064452749.1 MATE family efflux transporter -
A7J50_RS16330 3653787..3654359 - 573 WP_064452750.1 DUF2239 family protein -
A7J50_RS16335 3654427..3655383 - 957 WP_064452751.1 ATP-dependent Clp protease ATP-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9485.04 Da        Isoelectric Point: 9.6594

>T63236 WP_053256594.1 NZ_CP015600:3649900-3650151 [Pseudomonas antarctica]
VSKNEKLLAKLLNEHMAFTWPELVTLLHRLGYTQIEGAGSRVKFDIGDPSAMISLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T63236 NZ_CP015600:3649900-3650151 [Pseudomonas antarctica]
GTGTCAAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCACATGGCCTTTACCTGGCCAGAGCTCGTAACGCTGCT
GCATCGCTTGGGCTACACACAGATTGAAGGGGCTGGAAGCCGCGTCAAGTTCGACATCGGCGACCCCAGTGCAATGATCA
GCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13269.22 Da        Isoelectric Point: 6.9476

>AT63236 WP_064452746.1 NZ_CP015600:3650148-3650513 [Pseudomonas antarctica]
VNNQLKYKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCHALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHCTEPLPVLG

Download         Length: 366 bp

>AT63236 NZ_CP015600:3650148-3650513 [Pseudomonas antarctica]
GTGAACAACCAACTGAAATACAAAGGCTACATCGGCTCTATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
TCTGTTTATCAAGGCCTTGGTCAGCTACGAAGGGAAAACCGTCGCAGAGCTGGACGCTGCGTTCCGTGAGGCAGTCGATG
ACTACCTCGCGACATGCCACGCACTGGGGCAAACGCCGGAGAAGCCTTGCAAGGGCTCATTCAACGTACGGGTCGGCCAT
GACCTGCATTTGGCGGCGGCACTGGCCGCGACCCGTAAAAAAGTCACGCTCAATGACCTGACGCGCCAGGCGTTGAATGA
GTTCTTGCAGCATCACTGCACAGAACCTCTACCCGTGCTCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172Z267

Antitoxin

Source ID Structure
AlphaFold DB A0A172Z377

References